Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451701 |
ISSN: | 1984-8250 |
Autores: | Li, Yi1 Zhang, Peiyi2 Yang, Zhaowen2 Ma, Fang2 Savina3 Dhiman, Anju3 Li, Faxin2 |
Instituciones: | 1Center Hospital Affiliated to Shandong First Medical University, Department of Pharmacy, Jinan, Shandong. China 2Center Hospital Affiliated to Shandong First Medical University, Department of Rheumatology, Jinan, Shandong. China 3Maharshi Dayanand University, Department of Pharmaceutical Sciences, Haryana. India |
Año: | 2022 |
Volumen: | 58 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | In the present research investigation, various concentrations of hydro-alcoholic extract of Saraca asoca (Roxb.) De Wilde (family: Caesalpinaceae) dried bark and carbopol polymer at different temperature ranges were optimized for the preparation of gel formulation. Natural penetration enhancers, v.i.z., eucalyptus oil and peppermint oil were incorporated separately in the extract based gel formulations to study the rate of drug permeation across egg membrane, using franz diffusion cell. In vitro anti-arthritis potential of the formulations was also studied using inhibition of albumin denaturation, antiproteinase activity and membrane stabilization method. As per the results of current study, it is established that S. asoca dried bark hydroalcoholic extract based gel prepared using peppermint oil as penetration enhancer exhibited good permeation rate of 8.48% at the end of 3 h. The percentage inhibition of proteins by antiproteinase method at concentration of 50 µg/ml was 50.01±1.00% which was close to 53.92±0.99% as shown by the standard drug, Diclofenac. Also, the percent protein inhibition determined using membrane stabilization method was found to be 49.70±1.00%, however, it was 63.32±0.94% for the standard drug, Diclofenac. Hence, it is concluded that peppermint oil may act as a good candidate for the preparation of potent anti-rheumatic gel preparations |
Disciplinas: | Medicina |
Palabras clave: | Reumatología, Farmacología, Plantas medicinales, Artritis reumatoide, Geles, Extractos vegetales, Saraca asoca, Caesalpinaceae |
Keyword: | Rheumatology, Pharmacology, Medicinal plants, Rheumatoid arthritis, Gels, Plant extracts, Saraca asoca, Caesalpinaceae |
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