| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452037 |
| ISSN: | 1984-8250 |
| Autores: | Nogueira, Rodrigo José Lupatini1 Grazul, Richard Michael2 Silva Filho, Ademar Alves Da1 Nascimento, Jorge Willian Leandro3 |
| Instituciones: | 1Universidade Federal de Juiz de Fora, Faculdade de Farmacia, Juiz de Fora, Minas Gerais. Brasil 2Universidade Federal de Juiz de Fora, Instituto de Ciencias Exatas, Juiz de Fora, Minas Gerais. Brasil 3Universidade Federal de Juiz de Fora, Instituto de Ciencias Biologicas, Juiz de Fora, Minas Gerais. Brasil |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The administration of medications on the skin through transcutaneous routes is a practice that has been used by mankind for millennia. Some studies have been reporting the use of terpenes and natural oils rich in terpenes as an enhancer of cutaneous penetration. Copaiba oil, due to its rich content of terpenes, presents itself as a great choice of penetration enhancer for drugs administered on the skin. In this study, we developed two cream formulations containing 5% of ibuprofen (IBU) and copaiba oil: IBCO5 and IBCO10 with 5% and 10% of copaiba oil respectively. Ex vivo cutaneous penetration/permeation studies of IBU were performed using pig ear skin as biological membrane in the Franz-type diffusion cells. The steady-state flux of IBU samples, IBCO5 (35.72 ± 6.35) and IBCO10 (29.78 ± 2.41) were significantly higher when compared with control without copaiba oil (10.32 ±1.52) and with a commercial product (14.44 ± 2.39). In the penetration analysis, the amount of IBU found in the samples IBCO5 and IBCO10 was markedly higher in the dermis than epidermis. Our results showed that copaiba oil possesses attracting properties in promoting skin penetration and permeation of IBU when added into cream formulations |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Ibuprofeno, Aplicación tópica, Aceite de copaiba, Terpenos, Penetración dérmica |
| Keyword: | Medicinal chemistry, Ibuprofen, Topic administration, Copaiba oil, Terpenes, Skin penetration |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
