Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000452172 |
ISSN: | 1984-8250 |
Autores: | Luo, Caikui1 Wang, Yanming2 Zou, Jili1 Wu, Jinhu1 Meng, Junhua1 Zhou, Hanmin1 Chen, Yonggang1 |
Instituciones: | 1The Third Hospital of Wu-han, Wuhan, Hubei. China 2Shihezi University, Medical School, Shihezi, Xinjiang. China |
Año: | 2022 |
Volumen: | 58 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | This study aimed to establish and compare models of mammary gland hyperplasia (MGH) with hyperprolactinemia (HPRL) using two different methods. The models provide information on the relationship between mammary gland hyperplasia and associated hormones. Model A was constructed using intramuscular injections of estradiol benzoate injection (EBI), followed by progesterone (P), and then metoclopramide dihydrochloride (MDI). Model B was designed by administering MDI, follow by EBI, and then P intramuscularly. Model B showed higher MGH progression compared with model A. Notably, increase in estradiol (E2) was negatively correlated with prolactin (PRL) secretion. However, PRL levels in model B were significantly higher compared with the levels in model A. Estrogen (ER), prolactin receptor (PRLR), and progesterone receptor (PR) mRNA and protein expression levels in model B rats were positively correlated with changes in the corresponding hormone levels. However, E2, P, and PRL levels in model A showed no direct relationship with levels of the mRNAs of related hormones and protein expression levels. Our results suggest that model B is an appropriate model of MGH with HPRL that can be used to perform further studies about the interactions of the E2, P, and PRL hormones in this disorder |
Disciplinas: | Medicina |
Palabras clave: | Endocrinología, Farmacología, Medicina experimental, Estradiol, Progesterona, Prolactina, Hiperplasia mamaria, Hiperprolactinemia |
Keyword: | Endocrinology, Pharmacology, Experimental medicine, Estradiol, Progesterone, Prolactin, Mammary hyperplasia, Hyperprolactinemia |
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