Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000452238 |
ISSN: | 1984-8250 |
Autores: | Avoseh, Opeyemi Nudewhenu1 Ogunwande, Isiaka Ajani3 Oshikoya, Halimat Omolade2 |
Instituciones: | 1Vaal University of Technology, Faculty of Computer Science, Vanderbijlpark. Sudáfrica 2Lagos State University, Faculty of Science, Ojo, Lagos. Nigeria 3Foresight Institute of Research and Translation, Ibadan, Oyo. Nigeria |
Año: | 2022 |
Volumen: | 58 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Herein the chemical constituents and the anti-pain properties of the essential oil from the stem bark of Casuarina equisetifolia L. (Casuarinaceae) grown in Nigeria were evaluated. The essential oil was obtained by hydrodistillation method in an all glass Clevenger-type apparatus, and characterized by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The hot plate method was used to determine the anti-nociceptive property whereas the anti-inflammatory activity was evaluated by carrageenan-induced and formalin experimental models. The pale-yellow essential oil was obtained in yield of 0.21% (v/w), calculated on a dry weight basis. The main constituents of the essential oil were methyl salicylate (30.4%), a-zingiberene (15.5%), (E)-anethole (9.5%), b-bisabolene (8.6%), b- sesquiphellandrene (6.9%), and ar-curcumene (6.2%). In the anti-nociceptive study, the rate of inhibition increases as the doses of essential oil increases with optimum activity at the 30th and 60th min for all tested doses. The essential oil displayed anti-nociceptive activity independently of reaction time at the highest tested dose (200 mg/kg). The essential oil of C. equisetifolia moderately reduced pain responses in early and late phases of the formalin test. The oil inhibited the paw licking in the neurogenic phase (60-63%) compared to the late phase of the formalin test. The carrageenan- induced oedema model revealed the suppression of inflammatory mediators within the 1st - 3rd h. Thus, C. equisetifolia essential oil displayed both anti-nociceptive and anti-inflammatory activities independent of the dose tested. The anti-inflammatory and anti-nociceptive activities of C. equisetifolia essential oil are herein reported for the first time |
Disciplinas: | Química |
Palabras clave: | Farmacología, Fitoquímica, Aceites esenciales, Actividad antiinflamatoria, Actividad antinociceptiva, Casuarina equisetifolia, Casuarinaceae |
Keyword: | Pharmacology, Phytochemistry, Essential oils, Antiinflammatory activity, Antinociceptive activity, Casuarina equisetifolia, Casuarinaceae |
Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |