Emerging intervention of antidepressant with DMARD in non-cancerous nociceptive persistent pain associated depression in FCA induced rheumatoid arthritic rats
Título del documento: Emerging intervention of antidepressant with DMARD in non-cancerous nociceptive persistent pain associated depression in FCA induced rheumatoid arthritic rats
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451237
ISSN: 1984-8250
Autores: 1
2
1
Instituciones: 1Swamy Vivekanandha College of Pharmacy, Department of Pharmacology and Toxicology, Tiruchengode, Tamil Nadu. India
2C.L. Baid Metha College of Pharmacy, Department of Pharmacology, Chennai, Tamil Nadu. India
Año:
Volumen: 56
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Rheumatoid arthritis (RA) is a chronic inflammatory disorder that causes pain, systemic complications and premature mortality. Depression has also been identified as a problem for persons with RA. This association remaining significant even after the degree of disease activity is controlled. In the present study, the efficacy of combination therapeutic effect of antidepressant (amitriptyline) with Disease Modifying Anti rheumatoid drug (leflunomide) was determined in rheumatoid arthritis pain associated depression in Freund’s complete adjuvant (FCA) induced arthritic rats. Drug treatment was started 9 days after induction of FCA induced arthritis in rats. The antiarthritic activity was assessed by measuring paw volume, weight-bearing, hematological, biochemical, serological parameters, Radiographic analysis and Histopathology of tibiotarsal joints. The antidepressant activity was assessed by Forced swimming test, Rota-rod test and confirmed by estimation of brain neuro transmitters (serotonin and norepinephrine) level. Results of this study revealed that leflunomide and amitriptyline combination showed more significant (p<0.001) antiarthritic and antidepressant action and leflunomide alone treatment showed significant (p<0.001) antiarthritic activity only as compared to arthritic control. The leflunomide and low dose amitriptyline combination found to be more effective in pain associated depression in rheumatoid arthritic rats
Disciplinas: Química,
Medicina
Palabras clave: Farmacología,
Reumatología,
Psiquiatría,
Artritis reumatoide,
Depresión,
Amitriptilina,
Leflunomida,
Adyuvante de Freund,
Modelos animales
Keyword: Pharmacology,
Rheumatology,
Psychiatry,
Rheumatoid arthritis,
Depression,
Amitriptyline,
Leflunomide,
Freund adjuvant,
Animal models
Texto completo: Texto completo (Ver HTML) Texto completo (Ver PDF)