Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451443 |
ISSN: | 1984-8250 |
Autores: | Eke, Ifeanyi Gabriel1 Ezeh, Ikenna Onyema1 Ezeudu, Terry Adaeze1 Eze, Ukamaka Uchenna1 Anaga, Aruh Ottah1 Onyeyili, Patrick Azubuike1 |
Instituciones: | 1University of Nigeria, Faculty of Veterinary Medicine, Nsukka, Enugu. Nigeria |
Año: | 2020 |
Volumen: | 56 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | This study evaluated the efficacy of combination therapy of secnidazole-diminazene aceturate (SEC-DA) in late treatment of dogs experimentally infected with relapsing strain of Trypanosoma brucei brucei. Fifteen dogs were randomly assigned to 5 groups (A - E) of 3 per group. Group A (uninfected untreated), B (infected untreated), C (infected and treated with DA (3.5 mg/kg) IM stat), D (infected and treated with secnidazole (SEC) (100 mg/kg) orally for 5 days and DA (3.5 mg/kg) IM stat), E (infected and treated with SEC (200 mg/kg) orally for 5 days and DA (3.5 mg/kg) IM stat). Dogs were infected intraperitoneally with 5 x 105 trypanosomes and treatment started 14 days post-infection. Data on parasitaemia, hematology and rectal temperature were recorded. Parasitaemia cleared within 3 days in all the SEC-DA treated dogs and there was no relapse parasitaemia. Parasitaemia did not clear in DA monotherapy dogs. All the SEC-DA treated dogs showed significantly (P < 0.05) higher leucocyte counts, red blood cell count, packed cell volume, hemoglobin concentration and lower rectal temperature than DA monotherapy. It was, therefore, concluded that SEC-DA combination is therapeutically more efficacious than DA monotherapy in the late treatment of T.b. brucei infection in dogs |
Disciplinas: | Medicina veterinaria y zootecnia, Química |
Palabras clave: | Pequeñas especies, Parasitología, Farmacología, Secnidazol, Aceturato de diminazeno, Terapia combinada, Trypanosoma brucei, Perros |
Keyword: | Companion animals, Parasitology, Pharmacology, Secnidazole, Diminazene aceturate, Combined therapy, Trypanosomiasis, Dogs |
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