Distribution and antifungal susceptibility of Candida species isolated from clinical samples in southern Brazil
Título del documento: Distribution and antifungal susceptibility of Candida species isolated from clinical samples in southern Brazil
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451690
ISSN: 1984-8250
Autores: 1
2
2
3
1
Instituciones: 1Universidade do Vale do Itajai, Programa de PosGraduacao em Ciencias Farmaceuticas, Itajai, Santa Catarina. Brasil
2Universidade Regional de Blumenau, Departamento de Ciencias Farmaceuticas, Blumenau, Santa Catarina. Brasil
3Universidade Regional de Blumenau, Programa de Posgraduacao em Biodiversidade, Blumenau, Santa Catarina. Brasil
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Aplicado, descriptivo
Resumen en inglés Invasive infections caused by Candida species have been strongly associated with poor prognosis and high resistance rates to some antifungals. This study aimed to identify Candida species isolated from different anatomical sites and to describe their susceptibility profile to antifungals. Ninety-four clinical isolates of Candida were obtained from a Medical Laboratory of Santa Catarina/Brazil. Species identification was performed by MALDI-TOF MS. Susceptibility assays were performed as described by Clinical Laboratory Standard Institute (CLSI) microboth method. Among the analyzed samples, C. albicans was the pathogen most incident (59.9%) followed by C. parapsilosis complex (14.9%), C. glabrata complex (8.5%), and C. tropicalis (6.3%). 37 Candida strains were isolated from vaginal content (39.3%), 21 from the nail (22.4%), 8 from tracheal aspirates (8.5%), and 7 from urine (7.4%). Together, the Candida isolates presented decreased susceptibility to azole drugs, mainly to fluconazole and itraconazole. Amphotericin B showed sensibility in 95.7% of samples analyzed. Previous knowledge about etiology and antifungal susceptibility becomes indispensable to conduct an efficient treatment
Disciplinas: Medicina
Palabras clave: Ginecología y obstetricia,
Farmacología,
Candidiasis vulvovaginal,
Antifúngicos,
Azoles,
Resistencia a fármacos,
Candida albicans
Keyword: Gynecology and obstetrics,
Pharmacology,
Vulvovaginal candidiasis,
Antifungal agents,
Drug resistance,
Candida albicans,
Azoles
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