Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451923 |
ISSN: | 1984-8250 |
Autores: | Lecot, Nicole1 Rodríguez, Gonzalo2 Stancov, Valentina2 Fernández, Marcelo1 González, Mercedes2 Glisoni, Romina J2 Cabral, Pablo3 Cerecetto, Hugo1 |
Instituciones: | 1Universidad de la República, Centro de Investigaciones Nucleares, Montevideo. Uruguay 2Universidad de la República, Instituto de Química Biológica, Montevideo. Uruguay 3Universidad de Buenos Aires, Instituto de Nanobiotecnología, Buenos Aires. Argentina |
Año: | 2022 |
Volumen: | 58 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | In recent years, nanocarriers have been studied as promising pharmaceutical tools for controlled drug-delivery, treatment-efficacy follow-up and disease imaging. Among them, X-shaped amphiphilic polymeric micelles (Tetronic®, poloxamines) display great potential due to their biocompatibility and non-toxic effects, among others. In the present work, polymeric micelles based on the T1307 copolymer were initially decorated with a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-fluorophore in order to determinate its in vivo biodistribution on 4T1 tumor-bearing mice. However, unfavorable results with this probe led to two different strategies. On the one hand, the BODIPY-micelle-loaded, L-T1307-BODIPY, and on the other hand, the 99mTc-micelle-radiolabeled, L-T1307- 99m Tc, were analyzed separately in vivo. The results indicated that T1307 accumulates mainly in the stomach, the kidneys, the lungs and the tumor, reaching the maximum organ-accumulation 2 hours after intravenous injection. Additionally, and according to the results obtained for L-T1307- 99m Tc, the capture of the polymeric micelles in organs could be observed up to 24 hours after injection. The results obtained in this work were promising towards the development of new radiotracer agents for breast cancer based on X-shaped polymeric micelles |
Disciplinas: | Medicina |
Palabras clave: | Oncología, Diagnóstico, Cáncer, Marcadores moleculares, Micelios poliméricos, Marcadores radiopacos, Biodistribución, Tecnecio 99m |
Keyword: | Oncology, Diagnosis, Cancer, Molecular markers, Polymeric micelles, Radiopaque markers, Biodistribution, Technetium 99m |
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