Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451293 |
ISSN: | 1984-8250 |
Autores: | Guan, Jiao1 Han, Liqin1 Shi, Nianqiu1 Zhu, Heyun1 Wang, Junmin2 |
Instituciones: | 1Jilin Medical University, School of Pharmacy, Jilin. China 2Jilin Medical University, Affiliated Hospital, Jilin. China |
Año: | 2020 |
Volumen: | 56 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Docetaxel-loaded acetic acid conjugated Cordyceps sinensis polysaccharide (DTX-AA-CSP) nanoparticles were prepared through dialysis and their release rates in vitro, particle sizes, zeta potentials, drug loading capacities, and encapsulation efficiencies were characterized for the synthesis of AA-modified CSPs from traditional Chinese medicine Cordyceps sinensis (Berk.) Sacc. Then, the AA-modified CSPs were characterized by 1H-NMR and FT-IR. Furthermore, the biocompatibility of the delivery carrier (AA-CSP nanoparticles) was assessed on human umbilical vein endothelial cells. In vitro antitumor activity studies on DTX-AA-CSP nanoparticles were conducted on the human liver (HepG2) and colon cancer cells (SW480). The DTX-AA-CSP nanoparticles were spherical and had an average size of 98.91±0.29 nm and zeta potential within the −19.75±1.13 mV. The encapsulation efficiency and loading capacity were 80.95%±0.43% and 8.09%±0.04%, respectively. In vitro, DTX from the DTX-AA-CSP nanoparticles exhibited a sustained release, and the anticancer activities of DTX-AA-CSP nanoparticles against SW480 and HepG2 were significantly higher than those of marketed docetaxel injection (Taxotere®) in nearly all the tested concentrations. The AA-CSP nanoparticles showed good biocompatibility. This study provided a promising biocompatible delivery system for carrying antitumor drugs for cancer therapy |
Disciplinas: | Química |
Palabras clave: | Química farmacéutica, Sistemas de liberación de fármacos, Docetaxel, Nanopartículas, Polisacáridos, Cordyceps sinensis, Hypocreales, Biocompatibilidad |
Keyword: | Medicinal chemistry, Drug delivery systems, Docetaxel, Nanoparticles, Polysaccharides, Cordyceps sinensis, Hypocreales, Biocompatibility |
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