| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452150 |
| ISSN: | 1984-8250 |
| Autores: | Samanthula, Kumara Swamy1 Kumar CB, Mahendra4 Bairi, Agaiah Goud2 Satla, Shobha Rani3 |
| Instituciones: | 1Vaagdevi Pharmacy College, Bollikunta, Warangal. India 2SRR College of Pharmaceutical Sciences, Valbhapur, Warangal. India 3Centre for Pharmaceutical Sciences, Kukatpally, Hyderabad. India 4St. Mary’s College of Pharmacy, Secunderabad, Telangana. India |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Hydralazine hydrochloride is an anti-hypertensive drug. The drug has poor oral bioavailability (BA) of about 30- 50% due to extensive first-pass metabolism. Hence, the buccal delivery was used to enhance the BA of hydralazine hydrochloride. Buccal muco-adhesive tablets were prepared by direct compression technique, using carbopol 934P, HPMC K4M, sodium alginate and sodium carboxy methyl cellulose (NaCMC) as muco-adhesive polymers. Prepared formulations were evaluated for physico-chemical characterization, ex-vivo residence time and in-vitro release studies. The some of the parameters viz hardness, thickness, weight variation are showing the values within the pharmacopeial limits. However, the swelling and bio-adhesive strength were increased with increasing polymer concentrations. From the in-vitro release studies, F9 buccal tablets prepared with NaCMC exhibited better release (96.56%, 6 h) profile than all other formulations and considerd as optimized. The release mechanism from kinetic methods suggests that, the drug release follows zero-order kinetics with diffusion mechanism. Thus, the buccal tablets of hydralazine hydrochloride showed enhanced BA and were further confirmed by in-vivo studies |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Tabletas, Clorhidrato de hidralazina, Mucoadhesión |
| Keyword: | Medicinal chemistry, Tablets, Hydralazine hydrochloride, Mucoadhesion |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
