Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000452176 |
ISSN: | 1984-8250 |
Autores: | Vaz, Lilian Vieira1 Balcão, Victor Manuel1 Oliveira, José Martins1 Tubino, Matthieu2 Jozala, Angela1 Yoshida, Valquíria Miwa Hanai1 Vila, Marta Maria Duarte Carvalho1 |
Instituciones: | 1Universidade de Sorocaba, Laboratorio de Biofilms e Bacteriofagos, Sorocaba, Sao Paulo. Brasil 2Universidade Estadual de Campinas, Instituto de Quimica, Campinas, Sao Paulo. Brasil |
Año: | 2022 |
Volumen: | 58 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Hydrogels are interesting for use in the treatment of topical wounds due to their virtually zero toxicity, and capacity for extended release of pharmaceuticals. Silver sulfadiazine (SSDZ) is the drug of choice in the treatment of skin burns. The aim of the study was to determine cytotoxicity, antimicrobial activity and stability of a PVA hydrogel with integrated silver sulfadiazine. SSDZ-hydrogels were prepared using 10% (w/w) PVA (either 89% or 99% hydrolyzed) and 1% (w/w) silver sulfadiazine. Cellular viability was assessed via MTS assays, antimicrobial activity via disk-diffusion and accelerated stability tests were carried out with analysis at 0, 30, 60, 90 and 180 days of storage at 40 ± 2 °C and a relative humidity of 75 ± 5%. The parameters evaluated included organoleptic characteristics, moisture, swelling ability, mechanical strength, FTIR, XRD, TGA and DSC, and silver release patterns via XRD and potentiometry. Cell viability tests indicated some cytotoxicity, although within acceptable levels. After 90 days of storage, SSDZ hydrogel samples exhibited a brown coloration, probably due to the formation of Ag or Ag2O nanoparticles. The SSDZ-loaded hydrogels suffered visual and physical changes; however, these changes did not compromise its use as occlusive wound dressings or its antimicrobial properties |
Disciplinas: | Química |
Palabras clave: | Química farmacéutica, Sulfadiacina de plata, Hidrogeles, Aplicación tópica, Actividad antimicrobiana |
Keyword: | Medicinal chemistry, Silver sulfadiazine, Hydrogels, Topical application, Antimicrobial activity |
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