| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452126 |
| ISSN: | 1984-8250 |
| Autores: | Bobek, Vanessa Barbosa1 Cruz, Luiza Stolz2 Oliveira, Camila Freitas de1 Betim, Fernando Cesar Martins1 Swiech, Juliane Nadal Dias1 Folquitto, Daniela Gaspardo1 Ito, Carmen Antonia Sanches2 Budel, Jane Manfron2 Zanin, Sandra Maria Warumby1 Paula, Josiane de Fátima Padilha de2 Miguel, Obdúlio Gomes1 |
| Instituciones: | 1Universidade Federal do Parana, Programa de Pos-Graduacao em Ciencias Farmaceuticas, Curitiba, Parana. Brasil 2Universidade Estadual de Ponta Grossa, Programa de Pos-Graduacao em Ciencias Farmaceuticas, Ponta Grossa, Parana. Brasil |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The chemically complex essential oils of Baccharis species are associated with several biological activities, such as antimicrobial and antiulcerous properties. However, few studies have investigated Baccharis erioclada DC. Therefore, in this study, we aimed to characterize the essential oil of B. erioclada and evaluate its antioxidant, antimicrobial, and hemolytic potential. The essential oil was extracted by hydrodistillation using a Clevenger apparatus and analyzed via gas chromatography-mass spectrometry (GC-MS). Phosphomolybdenum complex formation, reducing antioxidant power, and thiobarbituric acid reactive substances (TBARS) methods were used to determine antioxidant potential. To evaluate the essential oil’s antimicrobial activity, minimum inhibitory concentrations (MIC) in Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans were calculated. Hemolytic activity was determined in sheep red blood cells. Thirty-one compounds were identified via GC-MS analysis, representing 81.60% of the total essential oil. These compounds included: turmerone (27.97%), fokienol (13.47%), ledol (9.78%), and santalol (5.35%). The class of compounds identified was the oxygenated sesquiterpenes (62.52%). Antioxidant activity was confirmed via phosphomolybdenum complex formation and TBARS methods. Moderate antimicrobial activity and low hemolysis rates were displayed at concentrations of 250 and 500 μg/mL |
| Disciplinas: | Biología, Química |
| Palabras clave: | Angiospermas, Fitoquímica, Aceites esenciales, Composición química, Actividad biológica, Baccharis erioclada, Asteraceae |
| Keyword: | Angiosperms, Phytochemistry, Essential oils, Chemical composition, Biological activity, Baccharis erioclada, Asteraceae |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
