| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452161 |
| ISSN: | 1984-8250 |
| Autores: | Rambo, Michele Andréia1 Soares, Krissie Daian1 Danielli, Letícia Jacobi1 Lana, Daiane Flores Dalla1 Bordignon, Sérgio Augusto de Loreto2 Fuentefria, Alexandre Meneguello1 Apel, Miriam Anders1 |
| Instituciones: | 1Universidade Federal do Rio Grande do Sul, Faculdade de Farmacia, Porto Alegre, Rio Grande do Sul. Brasil 2Centro Universitario La Salle, Programa de Graduacao em Evaluacao do Impacto Ambiental, Canoas, Rio Grande do Sul. Brasil |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Essential oils from four Ocotea species collected in southern Brazil were evaluated for chemical composition using gas chromatography coupled with mass spectrometry. The primary compound identified in O. acutifolia essential oil was an unsaturated tetracyclic diterpene, phyllocladene (67.7%), followed by a sesquiterpene hydrocarbon, β-selinene (18.0%). The sesquiterpene fraction was predominant in oils from two collections of O. puberula; β-caryophyllene (25.2%) and globulol (22.6%) were the major compounds identified in collections 1 and 2, respectively. O. silvestris essential oil contained predominantly germacrene D and bicyclogermacrene. These compounds were also predominant in essential oil from O. indecora leaves collected from shady habitats. By contrast, essential oil extracted from O. indecora grown under direct sunlight contained mainly oxygenated sesquiterpenes, such as guaiol (30.2%), α-eudesmol (27.6%), and β-eudesmol (12.7%). Chemotaxis assays showed that Ocotea essential oils had no significant inhibitory activity on leukocyte migration compared with a chemotactic stimulant (lipopolysaccharide from Escherichia coli). However, the oils exhibited antifungal activity against Candida parapsilosis, with a minimum inhibitory concentration of 500 µg/mL. To our knowledge, this is the first study to investigate the in vitro antifungal and antichemotactic activities of essential oils from Ocotea species native to southern Brazil |
| Disciplinas: | Biología, Química |
| Palabras clave: | Fitoquímica, Aceites esenciales, Actividad antifúngica, Ocotea, Lauraceae |
| Keyword: | Phytochemistry, Essential oils, Antifungal activity, Ocotea, Lauraceae |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
