| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451359 |
| ISSN: | 1984-8250 |
| Autores: | Shirinzadeh, Hanif1 Ghalia, Mohammed2 Tascioglu, Alev3 Adjali, Ferial Intissar2 Gunesacar, Gulsen1 Gurer Orhan, Hande3 Suzen, Sibel4 |
| Instituciones: | 1Erzincan Binali Yildirim University, Faculty of Pharmacy, Yalnizbag, Erzincan. Turquía 2Universite Mentouri-Constantine, Department of Chemistry, Constantine. Argelia 3Ege University, Faculty of Pharmacy, Izmir. Turquía 4Ankara University, Faculty of Pharmacy, Ankara. Turquía |
| Año: | 2020 |
| Volumen: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Melatonin (MLT) is a strong free radical scavenger that protects the body from the deleterious effects of excess oxidants. Synthesis of MLT analogue compounds with antioxidant potency has recently attracted the interest of researchers. In general, the strategy consists of modifying the groups in the different sites of the indole ring or replacing the indole ring with an analogue. As part of our ongoing research, the antioxidant capacity and cytotoxicity of newly synthesized MLT analogue naphthalene derivatives were evaluated. The radical scavenging activity was tested by a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Most of the synthesized compounds showed significant antioxidant activity in comparison to MLT. The structure-activity relationship was identified. The in vitro cytotoxic effects of the synthesized compounds were also investigated in CHO-K1 cells using the MTT assay |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Melatonina, Modificación bioisostérica, Naftaleno, Antioxidantes, Citotoxicidad |
| Keyword: | Medicinal chemistry, Melatonin, Bioisosteric modification, Naphthalene, Antioxidants, Cytotoxicity |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
