| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452220 |
| ISSN: | 1984-8250 |
| Autores: | Iqbal, Kashif1 Noor, Saba1 Shah, Akram2 Amin, Adnan3 |
| Instituciones: | 1IBADAT International University, Department of Pharmacy, Islamabad. Pakistán 2University of Peshawar, Department of Zoology, Peshawar, Khyber Pakhtunkhwa. Pakistán 3Gomal University, Faculty of Pharmacy, Peshawar, Khyber Pakhtunkhwa. Pakistán |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The aim was to scrutinize the in vivo and in vitro activities against Leishmania tropica with compounds of Oxyresveratrol, Quercetin O-Hexoside, and Quercetin 3-Glucoside. The in vitro outcomes against Leishmania were analyzed for 24-48 hours on L. tropica KWH23 promastigotes with compounds materials having 50 - 200 µg/mL concentration with negative control and standard drug Amphotericin B. The compounds were analyzed in L. tropica infected BALB/c mice against Leishmania tropica. The Quercetin 3-Glucoside shows mean inhibition of extracellular promastigotes after 48 hours at 50, 100, 150, 200 µg/mL were 91.02 ± 0.12, 94.50 ± 0.07, 96.15 ± 0.17 and 97.01 ± 0.08 % respectively. In BALB/c mice, the intracellular amastigotes were 91% cured at 200 µg/mL and mean lesion size decreased to 0.41 ± 0.21 mm (p < 0.01). The result shows that Quercetin 3-Glucoside possesses significant anti-leishmanial activity |
| Disciplinas: | Química |
| Palabras clave: | Farmacología, Microbiología, Quercetina 3-glucósido, Oxirresveratrol, Promastigotes, Leishmania tropica |
| Keyword: | Pharmacology, Microbiology, Quercetin 3-glucoside, Oxyresveratrol, Promastigotes, Leishmania tropica |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
