| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451137 |
| ISSN: | 1984-8250 |
| Autores: | Resende, Marina Ferrara de1 Lino, Cleudiomar Inácio1 Souza Fagundes, Elaine Maria de2 Rettore, Joao Vitor Paes3 Oliveira, Renata Barbosa de1 Labanca, Renata Adriana1 |
| Instituciones: | 1Universidade Federal de Minas Gerais, Faculdade de Farmacia, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Departamento de Fisiologia e Biofisica, Belo Horizonte, Minas Gerais. Brasil 3Universidade Federal de Juiz de Fora, Instituto de Ciencias Biologicas, Juiz de Fora, Minas Gerais. Brasil |
| Año: | 2019 |
| Volumen: | 55 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Diabetes mellitus is a chronic disease resulting in oxidative stress that promotes tissue damage. The appearance of this disease is highly related to lifestyle and food of the population, being of great interest to search for a dietary supplement that can also act by reducing oxidative alterations. Based on the broad range of biological activity of thiazole derivatives, this work aimed to evaluate the in vitro antioxidant activity of a novel hydrazine-thiazole derivative and studies in vivo. In in vivo experiments, the liver extracts of healthy and diabetic Wistar rats were used, with analysis to determine the enzymatic activity of SOD, CAT, GPx, and GR, and determination of lipid peroxidation. Finally, in the blood of these animals, biochemical parameters were evaluated. Statistical evidence of changes caused in liver enzymes and liquid peroxidation was not detected; however, these parameters were also not changed between control groups with and without diabetes. On the other hand, concerning biochemical parameters, significant differences were detected in uric acid, alkaline phosphatase, ALT, and urea, indicating a possible antioxidant protective role of such substances in the liver and kidney of diabetic animals that could be acting by means other than that commonly reported in the literature |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Endocrinología, Farmacología, Diabetes mellitus, Estrés oxidativo, Derivados de tiazol, Suplementos alimenticios, Curcumina |
| Keyword: | Endocrinology, Pharmacology, Diabetes mellitus, Oxidative stress, Curcumin, Thiazole derivatives, Feeding supplements |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
