Antidepressant-like effect of caffeic acid: Involvement of the cellular signaling pathways
Título del documento: Antidepressant-like effect of caffeic acid: Involvement of the cellular signaling pathways
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451781
ISSN: 1984-8250
Autores: 1
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Instituciones: 1Universidade do Vale do Itajai, Nucleo de Pesquisas Quimico-Farmaceuticas, Itajai, Santa Catarina. Brasil
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Caffeic acid is a phenolic compound widely distributed in plants and beverages such as coffee. Although its mechanism of action is poorly understood, caffeic acid reportedly induces antidepressant-like and neuroprotective effects. This study aimed to investigate the involvement of cellular signaling pathways in acute antidepressant-like effect induced by caffeic acid in mice. All procedures were approved by the Institutional Animal Ethics Committee of the UNIVALI n. 021/2013. Female Swiss mice were administered with vehicle, caffeic acid (5 mg/ kg, p.o.), inhibitor (H-89, U0126, chelerythrine, or PD9859, i.c.v.) or caffeic acid plus inhibitor. The behavioral effects were evaluated 1h after the administration of compounds to mice using tail suspension test (TST) and open field test (OFT). The results showed that the antidepressant- like effect of caffeic acid in mice was possibly mediated by the activation of PKA, MEK 1/2, PKC and MAPK (as assessed using TST), without compromising their locomotor activity (as assessed using OFT). Our results demonstrated, at least in part, the pathways involved in the neuroprotective and behavioral effects of caffeic acid
Disciplinas: Medicina,
Química
Palabras clave: Neurología,
Farmacología,
Acido cafeico,
Efectos antidepresivos,
Señalización celular
Keyword: Neurology,
Pharmacology,
Caffeic acid,
Antidepressant effects,
Cell signalling
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