| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452235 |
| ISSN: | 1984-8250 |
| Autores: | Raasch, Juliana Raquel1 Vargas, Tainara Gomes1 Santos, Andressa Schmidt dos1 Hahn, Roberta Ziles1 Silva, Anne Caroline Cezimbra da1 Antunes, Marina Venzon1 Linden, Rafael1 Betti, Andresa Heemann1 Perassolo, Magda Susana1 |
| Instituciones: | 1Universidade Feevale, Instituto de Ciencias da Saude, Novo Hamburgo, Rio Grande do Sul. Brasil |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Depression plays an important role in non-adherence to medical recommendations. Fluoxetine is a first line of depression treatment. This study aimed to evaluate adherence to drug therapy in fluoxetine users by different methods. A cross-section study was conducted with 53 depressed patients on fluoxetine for at least six months. Drug therapy adherence was assessed by validated questionnaires [Brief Medication Questionnaire (BMQ) and Morisky-Green test (MG)] and by the blood concentration of fluoxetine and its active metabolite norfluoxetine. Blood samples were taken before the daily first dose of fluoxetine. The plasmatic concentration of fluoxetine and norfluoxetine indicated that 58.5% volunteers were within the recommended therapeutic range and thus considered adherent to drug therapy. However, questionnaires indicated a non-adherent majority: 41.5% patients had a high degree of adherence in MG and only 13.2% were adherent to pharmacological treatment in BMQ. Most fluoxetine users showed a plasma concentration of fluoxetine and norfluoxetine within the therapeutic range, despite the low adherence to the drug therapy evaluated by the questionnaires. Thus, we suggest that plasma levels of fluoxetine and norfluoxetine could be used as the main method to check adherence to treatment |
| Disciplinas: | Medicina |
| Palabras clave: | Psiquiatría, Farmacología, Depresión, Fluoxetina, Norfluoxetina, Adherencia al tratamiento, Concentración plasmática |
| Keyword: | Psychiatry, Pharmacology, Depression, Fluoxetine, Norfluoxetine, Treatment adherence, Plasma concentration |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
