Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451352 |
ISSN: | 1984-8250 |
Autores: | Ahsan, Farogh1 Mahmood, Tarique1 Usmani, Shazia1 Bagga, Paramdeep1 Shamim, Arshiya1 Tiwari, Reshu1 Verma, Neeraj2 Siddiqui, Mohammed Haris3 |
Instituciones: | 1Integral University, Faculty of Pharmacy, Lucknow, Uttar Pradesh. India 2Hygia Institute of Pharmaceutical Education and Research, Department of Pharmacology, Lucknow, Uttar Pradesh. India 3Integral University, Department of Bioengineering, Lucknow, Uttar Pradesh. India |
Año: | 2020 |
Volumen: | 56 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | Cardiovascular diseases are the main source of death and morbidity in developed and developing nations. Animal models are required to propel our understanding of the pathogenesis, increase our knowledge, disease progress, and mechanism behind cardiovascular disorder, providing new approaches focused to improve the diagnostic and the treatment of these pathological conditions and additionally to test various therapeutic ways to deal with tissue regeneration and re-establish heart working following damage. A perfect model framework ought to be reasonable, effectively controlled, reproducible, and physiologically illustrative of human disease, show cardinal signs and pathology that resembles after the human ailment and ethically stable. The decision of selection of animal model should be considered precisely since it influences exploratory results and whether results of the research can be sensibly matched with the human. In this way, no specific technique splendidly reproduces the human disease, and relying upon the model, extra cost burden, resources, infrastructure and the necessity for technical hands, should also be kept under consideration. Here we have discussed and compiled various methods of inducing myocardial infarction in animals, basically by surgery, chemicals and through genetic modification, this may benefit the researchers in getting a complied data regarding various methods through which they can induce myocardial infarction in animals |
Disciplinas: | Medicina |
Palabras clave: | Sistema cardiovascular, Infarto al miocardio, Fisiopatogenia, Modelos animales, Isquemia |
Keyword: | Cardiovascular system, Myocardial infarction, Physiopathogenesis, Animal models, Ischeamia |
Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |