| Revista: | Brazilian journal of microbiology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000291101 |
| ISSN: | 1517-8382 |
| Autores: | Moreira, Maria Aparecida Scatamburlo1 Souza, Edmar Chartone de2 Moraes, Celia Alencar de |
| Instituciones: | 1Instituto de Biotecnologia Aplicada a Agropecuaria, Laboratorio de Microbiologia Industrial, Vicosa, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil |
| Año: | 2004 |
| Periodo: | Ene-Jun |
| Volumen: | 35 |
| Número: | 1-2 |
| Paginación: | 19-28 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Descriptivo |
| Resumen en inglés | Multidrug efflux mechanisms in bacteria contribute significantly to intrinsic and acquired resistance to antimicrobial agents. Genome analysis have confirmed the broad distribution of these systems in Gram-negative as well as in Gram-positive bacteria. Among resistance mechanisms, the multidrug efflux system or pump deserves special attention, since a cell that has acquired it can simultaneously diminish or even suppress the susceptibility to a wide range of antimicrobials. The efflux system is mediated by transport proteins which confer resistance to toxic compounds. In Gram-negative bacteria, a tripartite efflux system is necessary to expel the drug to the outer medium: a protein localized in the cytoplasmic membrane; another in the periplasmatic space (membrane fusion protein - MFP); and a third in the outer membrane (outer membrane factor - OMF). The drug transport is active, and depends either on the energy provided by ATP hydrolysis or is directly driven by the proton motive force. The transport proteins are grouped in families, according to the homology of the amino acid sequences and to similarity of mechanisms. Among Gram-negative bacteria, Escherichia coli and Pseudomonas aeruginosa have most of the hitherto identified and studied multidrug efflux systems |
| Disciplinas: | Biología, Medicina |
| Palabras clave: | Bacterias, Bacterias Gram negativas, Transporte, Proteínas, Multirresistencia, Antimicrobianos |
| Keyword: | Biology, Medicine, Bacteria, Gram negative bacteria, Multiresistance, Antimicrobial agents, Proteins, Transport |
| Texto completo: | Texto completo (Ver HTML) |
