131I-induced changes in rat thyroid gland function



Título del documento: 131I-induced changes in rat thyroid gland function
Revista: Brazilian journal of medical and biological research
Base de datos: PERIÓDICA
Número de sistema: 000351232
ISSN: 0100-879X
Autores: 1
3
3
1
2
3
4
1
Instituciones: 1Clinical Hospital Split, Department of Nuclear Medicine, Split. Croacia
2Clinical Hospital Split, Department of Pathology, Split. Croacia
3University of Split, School of Medicine, Split. Croacia
4University of Split, Faculty of Natural Sciences, Split. Croacia
Año:
Periodo: Ago
Volumen: 40
Número: 8
Paginación: 1087-1094
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Therapeutic doses of 131I administered to thyrotoxic patients may cause thyroid failure. The present study used a rat model to determine thyroid function after the administration of different doses of 131I (64-277 µCi). Thirty male Fisher rats in the experimental group and 30 in the control group (untreated) were followed for 6 months. The animals were 4 months old at the beginning of the experiment and were sacrificed at an age of 9 months. Hormone concentration was determined before 131I administration (4-month-old animals) and three times following 131I administration, when the animals were 7, 8, and 9 months old. The thyroid glands were removed and weighed, their volume was determined and histopathological examination was performed at the end of the experiment. Significant differences in serum triiodothyronine and thyroid-stimulating hormone concentration, measured at the age of 7, 8, and 9 months, were found in the experimental group. During aging of the animals, the concentration of thyroxin fell from 64.8 ± 8.16 to 55.0 ± 6.1 nM in the control group and from 69.4 ± 6.9 to 25.4 ± 3.2 nM in the experimental group. Thyroid gland volume and weight were significantly lower in the experimental than in the control group. Thyroid glands from the experimental group showed hyaline thickness of the blood vessel wall, necrotic follicles, a strong inflammatory reaction, and peeling of necrotic cells in the follicles. In conclusion, significant differences in hormone levels and histopathological findings indicated prolonged hypothyroidism after 131I administration to rats, which was not 131I dose dependent
Disciplinas: Medicina
Palabras clave: Endocrinología,
Medicina experimental,
Tiroides,
Función tiroidea,
Hormonas,
Iodo 131,
Histopatología
Keyword: Medicine,
Endocrinology,
Experimental medicine,
Thyroid gland,
Thyroid function,
Iodine 131,
Histopathology
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