| Revista: | Brazilian journal of chemical engineering |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000309081 |
| ISSN: | 0104-6632 |
| Autores: | Duarte, A.R.C1 Sousa, A.R. Sampaio de Sousa, H.C. de2 Gil, M.H.M Jespersen, H. T3 Duarte, C. M.M |
| Instituciones: | 1Instituto de Biologia Experimental e Tecnologica, Oeiras. Portugal 2Universidade de Coimbra, Departamento de Engenharia Quimica, Coimbra. Portugal 3Roskilde University, Center for Interdisciplinary Studies of Molecular Interactions, Roskilde. Dinamarca |
| Año: | 2006 |
| Periodo: | Jun |
| Volumen: | 23 |
| Número: | 2 |
| Paginación: | 191-196 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Biocompatible polymers and copolymers are frequently being used as part of controlled delivery systems. These systems can be prepared using a "clean and environment friendly" technology like supercritical fluids. One great advantage of this process is that compressed carbon dioxide has excellent plasticizing properties and can swell most biocompatible polymeric matrixes, thus promoting drug impregnation processes. Mass sorption of two acrylate biocompatible copolymers contact with supercritical carbon dioxide is reported. Equilibrium solubility of dense carbon dioxide in poly(methylmethacrylate-co-ethylhexylacrylate) and poly(methylmethacrylate-co-ethylhexylacrylate-co-ethyleneglycoldimethacrylate) was studied by a static method at 10.0 MPa and 313 K. The reticulated copolymer had Fickean behavior and its diffusion coefficient was calculated, under operating conditions |
| Disciplinas: | Química |
| Palabras clave: | Química de polímeros, Química farmacéutica, Materiales biocompatibles, Copolímeros de acrilato, Fluidos supercríticos |
| Keyword: | Chemistry, Medicinal chemistry, Polymer chemistry, Biocompatible materials, Acrylate copolymers, Supercritical fluids |
| Texto completo: | Texto completo (Ver HTML) |
