| Revista: | Brazilian archives of biology and technology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000362758 |
| ISSN: | 1516-8913 |
| Autores: | Muzell, Denise Pereira1 Lunardelli, Adroaldo2 Leite, Carlos Eduardo3 Fagundes, Rodrigo Medeiros2 Saciura, Vasyl Custodio2 Reichel, Carlos Luiz4 Oliveira, Jarbas Rodrigues de2 Astarita, Leandro Vieira1 |
| Instituciones: | 1Pontificia Universidade Catolica do Rio Grande do Sul, Laboratorio de Biotecnologia Vegetal, Porto Alegre, Rio Grande do Sul. Brasil 2Pontificia Universidade Catolica do Rio Grande do Sul, Laboratorio de Pesquisa em Biofisica Celular e Inflamacao, Porto Alegre, Rio Grande do Sul. Brasil 3Pontificia Universidade Catolica do Rio Grande do Sul, Instituto de Toxicologia, Porto Alegre, Rio Grande do Sul. Brasil 4Pontificia Universidade Catolica do Rio Grande do Sul, Laboratorio de Anatomia Patologica, Porto Alegre, Rio Grande do Sul. Brasil |
| Año: | 2013 |
| Periodo: | May-Jun |
| Volumen: | 56 |
| Número: | 3 |
| Paginación: | 383-392 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | This study assessed the bioactive properties of an aqueous extract of M. officinalis for its anti-inflammatory activity and its protection against hepatic and renal lesions induced by acetaminophen (APAP). Animals pre-treated with the crude extract in pleurisy induced by carrageenan showed a reduction in the amounts of exudate, in the numbers of leukocytes and polymorphonuclear cells. Intragastric administration of the extract for seven days prior to the APAP-induced lesion showed no protective effect on the liver. The treatment with the extract induced an increase of serum aspartate aminotransferase, indicating a rise of toxicity. Contrarily, the same treatment reduced the APAP induced lesion in kidney, with respect to ν-glutamyltransferase. The results suggested that the extract was not hepatoprotective and could lead to an increase in the lesions induced by the APAP. On the other hand, the extract was nephroprotective against the lesions induced by the APAP and showed an anti-inflammatory effect on pleurisy carrageenan-induced |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Medicina experimental, Actividad antiinflamatoria, Pleurisia, Hígado, Riñones, Plantas medicinales, Melissa officinalis |
| Keyword: | Medicine, Experimental medicine, Pharmacology, Antiinflammatory activity, Pleurisy, Liver, Kidneys, Medicinal plants, Melissa officinalis |
| Texto completo: | Texto completo (Ver HTML) |
