Fabrication and Characterization of Gliclazide Loaded Microcapsules
Título del documento: Fabrication and Characterization of Gliclazide Loaded Microcapsules
Revista: Brazilian archives of biology and technology
Base de datos: PERIÓDICA
Número de sistema: 000392550
ISSN: 1516-8913
Autores: 1
1
2
3
1
4
1
Instituciones: 1University of Sargodha, Faculty of Pharmacy, Sargodha. Pakistán
2University of Central Punjab, Faculty of Pharmacy, Lahore, Punjab. Pakistán
3COMSATS Institute of Information Technology, Department of Pharmacy, Abbottabad. Pakistán
4University of Punjab, College of Pharmacy, Lahore, Punjab. Pakistán
Año:
Periodo: Nov-Dic
Volumen: 57
Número: 6
Paginación: 874-881
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés This study aimed to formulate, characterize and evaluate the Gliclazide (GLZ) microcapsules prepared with sodium alginate, guar gum and pectin in different ratios by ionotropic-gelation method. The microcapsules were evaluated against different parameters such as particle size and shape, Carr’s index, Hausner’s ratio, rheological studies and drug release kinetics. Fourier Transform Infra Red (FTIR) and Differential Scanning Calorimetric (DSC) studies demonstrated the absence of any drug - polymers interaction. Promising characteristics were observed in rheological behavior and release kinetics. The size of microcapsules and percentage yield was in the range of 676 to 727 µm and 69 to 77%, respectively. Scanning electron micrographs revealed that microcapsules were discrete, spherical and free flowing. Entrapment efficiency and uniform drug release kinetics were some of the probable characteristics depicting the novel formulation design of Gliclazide microcapsules
Disciplinas: Química
Palabras clave: Química farmacéutica,
Microcápsulas,
Glicazide,
Goma guar,
Pectina
Keyword: Chemistry,
Medicinal chemistry,
Microcapsules,
Gliclazide,
Guar gum,
Pectin
Texto completo: Texto completo (Ver PDF)