| Revista: | Brazilian archives of biology and technology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000365601 |
| ISSN: | 1516-8913 |
| Autores: | Oliveira, Flavia Marcia1 Gusmao, Leandro Jose2 Cardoso, Valbert do Nascimento3 Ramaldes, Gilson Andrade3 Souza, Valeria Ruiz de4 Gontijo, Cristiano Machado4 |
| Instituciones: | 1Universidade Federal de Sergipe, Departamento de Educacao em Saude, Lagarto, Sergipe. Brasil 2Centro Universitario do Leste de Minas Gerais, Campus da Saude, Ipatinga, Minas Gerais. Brasil 3Universidade Federal de Minas Gerais, Faculdade de Farmacia, Belo Horizonte, Minas Gerais. Brasil 4Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil |
| Año: | 2013 |
| Periodo: | Jul-Ago |
| Volumen: | 56 |
| Número: | 4 |
| Paginación: | 581-586 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | The aim of this work was to evaluate the effects of ethanol on the adsorption and tissue distribution of orally administered antigens in mice. Results showed that ethanol reduced the level of anti-ovalbumin IgA antibodies in intestinal fluid for the mice treated orally with a palmitoyl–ovalbumin conjugate. Ethanol was administered intragastrically to mice at 5 g/kg body weight for 14 days (chronic treatment), or 10 g/kg body weight every 7th day up to 14 days (acute treatment). Thereafter, 99mtechnetium-labeled antigens were administered and lymphoid tissues were collected. Ethanol interfered with the transport of ovalbumin to the liver. Moreover, the transport of palmitoyl–ovalbumin to mesenteric lymph nodes was reduced 6 h after the antigen administration. In conclusion, there was a relationship between the suppression of ethanol-mediated specific local IgA responses and the decreased transport of palmitoyl–ovalbumin to mesenteric lymph nodes |
| Disciplinas: | Biología |
| Palabras clave: | Fisiología animal, Inmunología, Etanol, Antígenos, Respuesta inmune, Biodistribución, Ratones |
| Keyword: | Biology, Animal physiology, Immunology, Ethanol, Antigens, Immune response, Biodistribution, Mice |
| Texto completo: | Texto completo (Ver HTML) |
