Derivatives of 3H-spiro1-benzofuran-2, 1’-cyclohexanes: immunostimulants for veterinary use



Título del documento: Derivatives of 3H-spiro1-benzofuran-2, 1’-cyclohexanes: immunostimulants for veterinary use
Revista: Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas
Base de datos: PERIÓDICA
Número de sistema: 000374387
ISSN: 0717-7917
Autores: 1
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1
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1
Instituciones: 1Universidad de Santiago de Chile, Facultad de Química y Biología, Santiago de Chile. Chile
Año:
Volumen: 13
Número: 4
Paginación: 375-380
País: Chile
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Four 3H-spiro1-benzofuran-2, 1’-cyclohexanes were synthesized from filifolinol, two of which are reported for the first time. Docking molecular studies were carried out to determine in silico whether these derivatives have similar immunostimulant activity to that reported for filifolinol, and its oxidation product, filifolinone. Through of the study of interactions of these compounds with the heterodimer of the protein present in teleost TLR1-TLR2, filifolinol, 3’-filifolinchloride and filifolinyl acetate shows similar interactions between them, allowing to predict that they would have similar immunostimulant activity, but different to filifolinone and filifolinane or that they would act by a different mechanisms
Disciplinas: Medicina veterinaria y zootecnia,
Química
Palabras clave: Medicina veterinaria,
Farmacología,
Inmunoestimulantes,
Filifolinol,
3H-espirol-benzofurano-2, 1'-ciclohexanos
Keyword: Veterinary medicine and animal husbandry,
Chemistry,
Veterinary medicine,
Pharmacology,
Immunostimulants,
Filifolinol,
3H-spiro1-benzofuran-2, 1'-cyclohexanes
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