The role of thyroid hormone calorigenesis in the redox regulation of gene expression



Título del documento: The role of thyroid hormone calorigenesis in the redox regulation of gene expression
Revista: Biological research
Base de datos: PERIÓDICA
Número de sistema: 000269167
ISSN: 0716-9760
Autores: 1
2

Instituciones: 1Universidad de Chile, Programa de Biología Molecular y Celular, Santiago de Chile. Chile
2Universidad de Chile, Programa de Farmacología Clínica y Molecular, Santiago de Chile. Chile
Año:
Volumen: 39
Número: 4
Paginación: 611-617
País: Chile
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, analítico
Resumen en inglés Thyroid hormone (TH; 3,3',5-triiodothyronine, T3) is required for the normal function of most tissues, with major effects on 02 consumption and metabolic rate. These are due to transcriptional activation of respiratory genes through the interaction of T3-liganded TH receptors with TH response elements or the activation of intermediate factors, with the consequent higher production of reactive 02 species (ROS) and antioxidant depletion. T3-induced oxidative stress in the liver triggers the redox upregulation of the expression of cytokines (tumor necrosis factor-α [TNF-α], interleukin-10), enzymes (inducible nitric oxide synthase, manganese superoxide dismutase), and anti-apoptotic proteins (Bcl-2), via a cascade initiated by TNF-α produced by Kupffer cells, involving inhibitor of κB phosphorylation and nuclear factor-κB activation. Thus, TH calorigenesis triggers an expression pattern that may represent an adaptive mechanism to re-establish redox homeostasis and promote cell survival under conditions of ROS toxicity secondary to TH-induced oxidative stress. Mechanisms of expression of respiratory and redox-sensitive genes may be functionally integrated, which could be of importance to understand the complexities of TH action and the outcome of thyroid gland dysfunction
Disciplinas: Química,
Medicina
Palabras clave: Bioquímica,
Metabolismo y nutrición,
Genética,
Hormonas tiroideas,
Calorigénesis,
Estrés oxidativo,
Expresión génica
Keyword: Chemistry,
Medicine,
Biochemistry,
Metabolism and nutrition,
Thyroid hormones,
Calorigenesis,
Oxidative stress,
Gene expression,
Genetics
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