Association of interleukin-10 -1082 A/G (rs1800896) polymorphism with susceptibility to gastric cancer: meta-analysis of 6,101 cases and 8,557 controls
Título del documento: Association of interleukin-10 -1082 A/G (rs1800896) polymorphism with susceptibility to gastric cancer: meta-analysis of 6,101 cases and 8,557 controls
Revista: Arquivos de gastroenterologia = Archives of gastroenterology
Base de datos: PERIÓDICA
Número de sistema: 000418748
ISSN: 0004-2803
Autores: 1
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Instituciones: 1Shahid Sadoughi University of Medical Sciences, Department of Internal Medicine, Yazd. Irán
2Shahid Sadoughi University of Medical Sciences, Department of Emergency Medicine, Yazd. Irán
3Arak University of Medical Sciences, Department of Endodontic, Arak. Irán
4Arak University of Medical Sciences, Department of Pediatric Dentistry, Arak. Irán
5Arak University of Medical Sciences, Department of Restorative and Esthetic, Arak. Irán
6Shahid Beheshti University of Medical Sciences, Department of Forensic Medicine, Teherán. Irán
7Shahid Sadoughi University of Medical Sciences, Mother and Newborn Health Research Center, Yazd. Irán
Año:
Periodo: Ene-Mar
Volumen: 55
Número: 1
Paginación: 33-40
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés The promoter -1082 A/G (rs1800896) polymorphism of Interleukin-10 (IL-10) gene have been widely reported and considered to have a significant role on gastric cancer risk, but the results are inconsistent. Objective – To clarify the association, we conducted a meta-analysis to investigate the associations IL-10 -1082 A/G polymorphism with gastric cancer. Methods – Eligible articles were identified by searching databases including PubMed, Web of Science, and Google Scholar up to August 03, 2017. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. Results – A total of 30 case-control studies with 6,101 cases and 8,557 controls were included in this meta-analysis. Overall, a significant association between IL-10 -1082 A/G polymorphism and gastric cancer risk was observed under the allele model (G vs A: OR=1.305, 95% CI=1.076-1.584; P=0.007), heterozygote model and (GA vs AA: OR=1.252, 95% CI=1.252-1.054; P=0.011) and dominant model (GG+GA vs AA: OR=1.264, 95% CI=1.053-1.516; P=0.012). In the subgroup analysis by ethnicity, increased gastric cancer risk were found in Asians under the allele model (G vs A: OR=1.520, 95% CI=1.172-1.973; P=0.002), homozygote model (GG+GA vs AA: OR=1.571, 95% CI=1.023- 2.414; P= 0.039), heterozygote model (GA vs AA: OR=1.465, 95% CI=1.192-1.801; P≤0.001) and dominant model (GG+GA vs AA: OR=1.448, 95% CI=1.152-1.821; P=0.002), but not among Caucasian and Latinos populations. Conclusion – These results suggested that the IL-10 -1082 A/G (rs1800896) polymorphism might contribute to the gastric cancer susceptibility, especially among Asians
Resumen en portugués O promotor-1082 A/polimorfismo G (rs1800896) do gene da interleucina-10 (IL-10) é amplamente relatado e considerado por ter um papel significativo no risco de câncer gástrico, porém os resultados são inconsistentes. Objetivo – Para esclarecer melhor esta associação, realizou-se uma meta-análise para investigar as associações de IL-10-1082 A/polimorfismo G com câncer gástrico. Métodos – Artigos elegíveis foram identificados através de pesquisa de bases de dados PubMed, Web of Science e Google Scholar até 3 de agosto de 2017. Razões de possibilidades (OR) com intervalo de confiança de 95% correspondente (CIs) foram usados para avaliar a associação. Resultados – Um total de 30 estudos de caso-controle, 6.101 casos e com 8.557 controles foram incluídos nesta meta-análise. Em geral, uma associação significativa entre IL-10-1082 A/G polimorfismo e risco de câncer gástrico foi observada sob o modelo de alelo (G vs A: OR=1.305, 95% CI=1.076-1.584; P=0.007), no modelo heterozigoto (GA vs AA: OR=1.252, 95% CI=1.252-1.054; P=0.011) e modelo dominante (GG+GA vs AA: OR=1.264, 95% CI=1.053-1.516; P=0.012). Na análise de subgrupo pela etnia, foi encontrado risco aumentado de câncer gástrico em asiáticos sob o modelo de alelo (G vs A: OR=1.520, 95% CI=1.172-1.973; P=0.002), modelo heterozigoto (GG+GA vs AA: OR=1.571, 95% CI=1.023-2.414; P= 0.039), e modelo dominante (GG+GA vs AA: OR=1.448, 95% CI=1.152-1.821; P=0.002), mas não entre a população caucasiana e latina. Conclusão – Estes resultados sugeriram que a IL-10-1082 A/polimorfismo G (rs1800896) pode contribuir para a suscetibilidade de câncer gástrico, especialmente entre os asiáticos
Disciplinas: Medicina
Palabras clave: Gastroenterología,
Oncología,
Genética,
Neoplasias,
Estómago,
Polimorfismo genético,
Interleucina 10,
Meta-análisis
Keyword: Gastroenterology,
Oncology,
Genetics,
Neoplasms,
Stomach,
Genetic polymorphism,
Interleukin 10,
Meta-analysis
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