| Revista: | Archivos venezolanos de farmacología y terapéutica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000438277 |
| ISSN: | 0798-0264 |
| Autores: | Rojas, Joselyn1 Calvo Delgado, María José1 Chávez, Carmen1 Chávez Castillo, Mervin1 Mejía, Lidia1 Salazar, Juan1 Olivar, Luis1 Graterol Rivas, Modesto2 Wilches Durán, Sandra2 Contreras Velásquez, Julio2 Graterol Silva, Rosemily2 Bermúdez, Valmore1 |
| Instituciones: | 1Universidad del Zulia, Facultad de Medicina, Maracaibo, Zulia. Venezuela 2Universidad Simón Bolívar, Grupo de Investigación Altos Estudios de Frontera, Cúcuta, Norte de Santander. Colombia |
| Año: | 2016 |
| Volumen: | 35 |
| Número: | 4 |
| Paginación: | 92-99 |
| País: | Venezuela |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Mast Cell Activation Disease (MCAD) is characterized by abnormal proliferation of mastocytes, where clinical manifestations arise from the excess release of these cells’ mediators. This case report concerns a 34-year old male patient who seeks medical attention after 5 months presenting recurring episodes of intense facial flushing with local edema, erythema, and increased volume of the ears and lips, without signs of angioedema. Other symptoms included burning oropharyngeal pain, vascular-type headache and hypotension. These crises occurred predominantly during nighttime and lasted 20-60 minutes, and were often associated with prolonged exposure to sunlight, high temperatures and psychological stress; constituting a clinical picture compatible with MCAD, supported by laboratory findings. Treatment began with ebastine, deflazacort, montelukast, ranitidine and omega-3 fatty acids, without clinical improvement, leading to substitution of this regimen with sodium chromoglycate and initiation of an immunomodulatory diet. This plan achieved satisfactory symptomatic resolution, confirming the diagnosis and highlighting the importance of adequate pharmacologic intervention. During a control consultation, the patient reported nocturnal episodes of tachycardia, palpitations and anxiety unrelated to the flushing crises, which prompted thyroid evaluation, revealing autoimmune thyroid disease with subclinical hyperthyroidism, which was managed with methimazol without complications |
| Disciplinas: | Medicina |
| Palabras clave: | Endocrinología, Inmunología, Enfermedades autoinmunes, Mastocitosis, Enfermedad por activación de mastocitos, Histamina, Enfermedad tiroidea autoinmune |
| Keyword: | Endocrinology, Immunology, Autoimmune diseases, Mastocytosis, Mast cells activation disease, Histamine, Autoimmune thryoid disease |
| Texto completo: | https://biblat.unam.mx/hevila/Archivosvenezolanosdefarmacologiayterapeutica/2016/vol35/no4/3.pdf |
