Ten years after the FDA black box warning for antidepressant drugs: a critical narrative review



Título del documento: Ten years after the FDA black box warning for antidepressant drugs: a critical narrative review
Revista: Archives of clinical psychiatry
Base de datos: PERIÓDICA
Número de sistema: 000402054
Autores: 1
1
1
1
Instituciones: 1Universidad de Valparaíso, Facultad de Medicina, Valparaíso. Chile
Año:
Periodo: May-Jun
Volumen: 43
Número: 3
Paginación: 60-66
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés The United States Food and Drug Administration (FDA) has warned about the increased suicidality risk associated with the use of selective serotonin reuptake inhibitors (SSRI) and venlafaxine in children and adolescents. Objectives To critically appraise the available evidence supporting the FDA Black box warning concerning to the use of antidepressants in child and adolescents. Methods A critical review of articles in Medline/PubMed and SciELO databases regarding the FDA Black box warning for antidepressants, and the impact of FDA warnings on antidepressant prescriptions and suicide rates. Results The warning was based on surveys that did not report either cases of suicide nor a significant difference supporting an increased suicidality rate. The concept was defined in an ambiguous way and there is currently more available evidence to support such definition. The use of SSRI and venlafaxine has been associated to lower suicidality rates, but the prescription fall due to the warning increased suicide rates. Discussion Suicidality is an inherent feature of depressive disorders so it would be desirable to consider how much of the phenomenon may be attributed to antidepressants per se. It would be appropriate to consider that suicide rates might increase also as a consequence of the warning
Disciplinas: Medicina
Palabras clave: Farmacología,
Psiquiatría,
Antidepresivos,
Inhibidores de la recaptación de serotonina,
Venlafaxina,
Suicidio,
Regulación sanitaria
Keyword: Medicine,
Pharmacology,
Psychiatry,
Antidepressants,
Serotonin uptake inhibitors,
Venlafaxine,
Suicide,
Sanitary regulation
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