Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment
Título del documento: Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment
Revista: Archives of clinical psychiatry
Base de datos: PERIÓDICA
Número de sistema: 000428713
Autores: 1
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Instituciones: 1Bezmialem Vakif University, Department of Psychiatry, Estambul. Turquía
Año:
Periodo: Ene-Feb
Volumen: 46
Número: 1
Paginación: 9-13
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Not only white blood cells but also platelets are being considered in inflammatory reactions from now on. Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) have been shown to change in inflammatory diseases like myocardial infarction, stroke and implicated in psychiatric disorders nowadays. Our first aim is to investigate the relation of MPV and NLR with depression and secondly to assess if they change with the treatment of depression. Methods Forty-nine patients diagnosed with major depressive disorder (MDD) and hospitalized in a university hospital psychiatry inpatient unit retrospectively included in the study. Control group consisted of 48 hospital workers with no known disease. Complete blood count, Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impression-Severity Scale (CGI-S) scores at admission and at discharge were noted and compared for the patient group. Discussion MPV of depressed patients was higher than controls. When we look at admission and discharge scores of clinical scales, decrement is statistically significant for both HAM-D and CGI-S. There was decline both in MPV and NLR which were both statistically significant. Conclusion Decreasing MPV and NLR values with the treatment of depression confirm the involvement of inflammatory processes in the pathophysiology of depression
Disciplinas: Medicina
Palabras clave: Psiquiatría,
Farmacología,
Hematología,
Depresión,
Antidepresivos,
Inflamación,
Volumen plaquetario medio,
Relación neutrófilos-linfocitos
Keyword: Psychiatry,
Pharmacology,
Hematology,
Depression,
Antidepressants,
Inflammation,
Mean platelet volume,
Neutrophil-lymphocyte ratio
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