Association of synaptosomal-associated protein 25 (SNAP-25) gene polymorphism with temperament and character traits in women with fibromyalgia syndrome
Título del documento: Association of synaptosomal-associated protein 25 (SNAP-25) gene polymorphism with temperament and character traits in women with fibromyalgia syndrome
Revista: Archives of clinical psychiatry
Base de datos: PERIÓDICA
Número de sistema: 000419393
Autores: 1
2
3
4
5
Instituciones: 1Dr. Ersin Arslan Training and Research Hospital, Department of Internal Medicine, Gaziantep. Turquía
2Antalya Training and Research Hospital, Department of Internal Medicine, Antalya. Turquía
3Pamukkale University, Department of Medical Biology, Denizli. Turquía
4Pamukkale University, Department of Psychiatry, Denizli. Turquía
5Pamukkale University, Department of Internal Medicine, Denizli. Turquía
Año:
Periodo: Jul-Ago
Volumen: 45
Número: 4
Paginación: 88-93
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Synaptosomal-associated protein 25 (SNAP-25) may be contribute to the pathogenesis of fibromyalgia Syndrome (FMS) by affecting the release of neurotransmitters. Objectives: We aimed to investigate the relationship between the SNAP-25 gen (DdeI = rs1051312 and MnlI = rs3746544) polymorphism and the temperament and character traits. Methods: A total of 85 female patients diagnosed with FMS and 70 age-matched healthy female subjects were enrolled into the study. The Temperament and Character Inventory (TCI) were performed on all the patients. SNAP-25 gene polymorphism was determined in the patients group and controls group. Results: No significant difference between groups was found regarding the distribution of SNAP-25 MnlI polymorphism (p > 0.05), but it was seen that the frequency of TC genotype for DdeI gene was higher in the patients group (p < 0.05). Increased hazard avoidance was found in the patients group (p < 0.05). When TCI scores were assessed in terms of SNAP-25 gene polymorphism, no statistically significant relationship was detected between the TT, TG, GG genotypes for MnlI gen and TCI scores (p > 0.05). However, increased hazard avoidance was detected in patients with TC genotype for DdeI gene compared to patients without such genotype. Discussion: SNAP-25 might be an etiological factor in FMS pathogenesis and might affect personality traits of FMS patients by mediating neurotransmitter release
Disciplinas: Medicina
Palabras clave: Psiquiatría,
Neurología,
Fibromialgia,
Patogénesis,
Polimorfismo genético
Keyword: Psychiatry,
Neurology,
Fibromyalgia,
Pathogenesis,
Genetic polymorphism
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