| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000416604 |
| ISSN: | 1665-2681 |
| Autores: | Ladero, José M1 Torrejón, María J2 Sánchez Pobre, Pilar2 Suárez, Avelina2 Cuenca, Francisca2 Orden, Virginia de la3 Devesa, María J2 Rodrigo, María4 Estrada, Vicente4 López Alonso, Gustavo2 Agúndez, José A5 |
| Instituciones: | 1Universidad Complutense de Madrid, Facultad de Medicina, Madrid. España 2Hospital Clínico San Carlos, Instituto de Investigación Sanitaria , Madrid. España 3Hospital Clínico San Carlos, Unidad de Genómica, Madrid. España 4Hospital Clínico San Carlos, Servicio de Medicina Interna, Madrid. España 5Universidad de Extremadura, Departamento de Farmacología, Cáceres. España |
| Año: | 2013 |
| Periodo: | Mar-Abr |
| Volumen: | 12 |
| Número: | 2 |
| Paginación: | 199-204 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, caso clínico |
| Resumen en inglés | Vitamin D has immunomodulatory properties, exerts an anti-hepatitis C virus (HCV) effect in vitro and improves response to interferon-based therapy in patients with chronic hepatitis C (CHC). Low serum levels of 25(OH) vitamin D [25(OH)D] are frequently found in CHC patients and seem to be related to more advanced stages of liver fibrosis. The study aims to establish the incidence of vitamin D deficiency in Spanish patients with CHC, its possible relation with features of liver damage and with the IL28B gene polymorphism, and the immediate effect of vitamin D therapy on CHC-related analytical variables. Materials and methods. Baseline serum 25(OH)D levels were measured in 108 consecutive CHC patients (60 men, age 54.3 ± 10.5 yrs). Results of transient elastography and of IL28B rs12979860C/T genotype were available in 89 and 95 patients, respectively. Forty one patients with insufficient levels of 25(OH)D received vitamin D supplements and were re-evaluated thereafter. Results. Deficiency of vitamin D (< 20 µg/dL) and suboptimal levels (20-30 µg/mL) were detected in 36.1% and 40.9% of patients, respectively. No relationships were found between 25(OH)D levels and biochemical liver tests, fibrosis stage and IL28B genotype. Vitamin D therapy normalized 25(OH)D levels in all treated patients, but did not modify significantly HCV-RNA serum levels or biochemical tests. Conclusions. Vitamin D deficiency is common in Spanish patients with CHC but it is related neither to biochemical and virological variables nor with the fibrosis stage and IL28B polymorphism. Vitamin D therapy has no immediate effect on HCV-RNA serum levels |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Terapéutica y rehabilitación, Hepatitis C, Vitamina D, Calcitriol, Fibrosis, Hepatitis crónica |
| Keyword: | Gastroenterology, Therapeutics and rehabilitation, Hepatitis C, Vitamin D, Calcitriol, Fibrosis, Chronic hepatitis |
| Texto completo: | Texto completo (Ver PDF) |
