Role of nitric oxide in liver regeneration



Título del documento: Role of nitric oxide in liver regeneration
Revista: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000419052
ISSN: 1665-2681
Autores: 1
1
Instituciones: 1Universidad Nacional de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Santa Fe. Argentina
Año:
Periodo: Sep-Oct
Volumen: 11
Número: 5
Paginación: 636-647
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés The liver has a remarkable ability to regenerate in response to surgical removal or chemical insult. The mechanisms regulating regenerative processes are complex, and incompletely understood. A large number genes, which are not normally expressed in the quiescent liver, are activated. Immediately after partial hepatectomy (PH) (1-6 h), nitric oxide (NO) is synthesized by liver parenchymal and nonparenchymal cells from L-arginine, via induction of the inducible form of nitric oxide synthase (iNOS). NO is a highly reactive molecule, known to be involved in diverse biological processes in nearly all aspects of life. Liver regeneration is a major area within the field of NO research. Our review describes several processes that have been suggested to be modulated by the NO released following PH, including proliferation, apoptosis and angiogenesis in the remnant tissue. Because iNOS up regulation has such profound physiologic effects, its regulation is strictly controlled. The up regulation of iNOS after PH and the subsequent production of NO induce positive effects on the regulation of early stages of the regenerative process. However, overproduction (> 100%) can have detrimental effects, including apoptosis. Thus, the iNOS induction after PH is necessary, and enough to allow for the normal regenerative process
Disciplinas: Medicina
Palabras clave: Gastroenterología,
Bioquímica,
Regeneración hepática,
Oxido nítrico,
Factor de crecimiento del endotelio vascular,
Apoptosis,
Estrés oxidativo
Keyword: Gastroenterology,
Biochemistry,
Liver regeneration,
Nitric oxide,
Vascular endothelial growth factor,
Apoptosis,
Oxidative stress
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