| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000415040 |
| ISSN: | 1665-2681 |
| Autores: | Tellez Avila, Félix1 Sifuentes Osornio, José2 Barbero Becerra, Varenka3 Franco Guzmán, Ada3 Ruiz Cordero, Roberto3 Alfaro Lara, Roberto3 Hernández Ramírez, Angeles3 Vargas Vorackova, Florencia |
| Instituciones: | 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Endoscopia, México, Distrito Federal. México 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Enfermedades Infecciosas, México, Distrito Federal. México 3Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Gastroenterología, México, Distrito Federal. México |
| Año: | 2014 |
| Periodo: | Ene-Feb |
| Volumen: | 13 |
| Número: | 1 |
| Paginación: | 65-74 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | There is scarce information about primary prophylaxis in cirrhotic patients. The aim was to assess the efficacy of ciprofloxacin for primary prophylaxis for bacterial infections in patients with cirrhosis of the liver and ascites. Material and methods. A randomized, double-blind placebo-controlled clinical trial was conduced. Patients were randomized to receive oral ciprofloxacin 500 mg/day or placebo for one month. A basal evaluation and repeated assessments at 4, 6, 12, 18, and 24 weeks afterwards, or whenever a primary endpoint occurred were done. Statistical analysis: probability curves were constructed with the Kaplan-Meier method and compared by the log-rank test. Results. 95 patients were randomized to ciprofloxacin group (n = 49; 51.6%) and placebo group (n = 46; 48.4%). Six-teen (32.6%) patients in the ciprofloxacin group developed bacterial infections and thirteen (28.2%) patients developed bacterial infections in the placebo group (p = NS). The probability to remain free of bacterial infections did not reach statistical significance (p = 0.38). Probability of survival at 24 weeks was 91% in placebo group and 98% in the ciprofloxacin group (p = 0.28). The absolute risk reduction was 5%, the relative risk reduction was 6% and the NNT was 20 patients. Conclusion. Primary prophylaxis with ciprofloxacin for one month in cirrhotic patients with ascites who do not have a currently accepted indication, did not show a preventive effect on the development of bacterial infections at one month follow-up. Moreover in women could increases the odds for UTI. The administration of ciprofloxacin seemed to decrease the risk of mortality |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Terapéutica y rehabilitación, Cirrosis hepática, Infecciones bacterianas, Profilaxis, Ciprofloxacina, Peritonitis bacteriana espontánea |
| Keyword: | Medicine, Gastroenterology, Therapeutics and rehabilitation, Liver cirrhosis, Bacterial infections, Prophylaxis, Ciprofloxacin, Spontaneous bacterial peritonitis |
| Texto completo: | Texto completo (Ver PDF) |
