| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000411756 |
| ISSN: | 1665-2681 |
| Autores: | Chávez Tapia, Norberto1 Torres Sánchez, Jorge1 Romero Flores, Juan1 Alvarez Quiroz, Paulina1 Ramírez Alvarez, Sandra1 Juárez Hernández, Eva1 Pérez Jáuregui, José2 Méndez Sánchez, Nahum3 Uribe, Misael3 |
| Instituciones: | 1Fundación Clínica Médica Sur, Unidad de Enfermedades Digestivas y Obesidad, México, Distrito Federal. México 2Fundación Clínica Médica Sur, Laboratorio Clínico, México, Distrito Federal. México 3Fundación Clínica Médica Sur, Unidad de Investigación de Hígado, México, Distrito Federal. México |
| Año: | 2015 |
| Periodo: | Jul-Ago |
| Volumen: | 14 |
| Número: | 4 |
| Paginación: | 524-530 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Transient elastography (TE) is a useful tool for the assessment of hepatic fibrosis as an alternative to liver biopsy, but it has not been validated as a screening procedure in apparently healthy people. Aim. To determine the prevalence of advanced liver fibrosis diagnosed by TE in a socioeconomically challenged rural population. Material and methods. We enrolled 299 participants aged over 18 years old from a vulnerable population in Mexico who responded to an open invitation. All participants had their history recorded and underwent a general clinical examination and a liver stiffness measurement, performed by a single operator according to international standards. Results. Overall, 7.35% participants were found to be at high risk for cirrhosis. Three variables correlated with a risk for a TE measure ≥ 9 kPa and significant fibrosis: history of alcohol intake [7.95 vs. 92.04%, odds ratio (OR) 4.47, 95% confidence interval (CI) 1.45-13.78, P = 0.0167], body mass index (BMI) ≥ 30 kg/m2 (30.87 vs. 69.12%, OR 4.25, 95%CI 1.04-6.10, P = 0.049), and history of diabetes mellitus (14.87 vs. 85.12%, OR 2.76, 95%CI 1.002-7.63, P = 0.0419). In the multivariate analyses BMI ≥ 30 kg/m2 was the only significant risk factor for advanced liver fibrosis or cirrhosis (OR 2.54, 95%CI 1.02-6.3, P = 0.0460). Conclusion. TE could be useful as a screening process to identify advanced liver fibrosis in the general and apparently healthy population |
| Disciplinas: | Medicina |
| Palabras clave: | Diagnóstico, Gastroenterología, Cirrosis hepática, Técnicas de diagnóstico, Elastografía transitoria, Indice de masa corporal, Morbilidad, Fibrosis hepática |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Liver cirrhosis, Diagnostic techniques, Transient elastography, Body mass index, Morbidity, Liver fibrosis |
| Texto completo: | Texto completo (Ver PDF) |
