Revista: | Annals of hepatology |
Base de datos: | PERIÓDICA |
Número de sistema: | 000407815 |
ISSN: | 1665-2681 |
Autores: | Yoshida, Eric M1 Kwo, Paul2 Agarwal, Kosh3 Duvoux, Christophe4 Durand, Francois5 Peck Radosavljevic, Markus6 Lilly, Leslie7 Willems, Bernard8 Vargas, Hugo9 Kumar, Princy10 Brown-Junior, Robert S11 Horsmans, Yves12 De Oertel, Shampa13 Arterburn, Sarah13 Dvory Sobol, Hadas13 Brainard, Diana M13 McHutchison, John G13 Terrault, Norah14 Rizzetto, Mario15 Mullhaupt, Beat16 |
Instituciones: | 1Vancouver General Hospital, Division of Gastroenterology, Vancouver, Columbia Británica. Canadá 2Indiana University, School of Medicine, Indianapolis, Indiana. Estados Unidos de América 3King’s College Hospital Foundation Trust, Institute of Liver Studies, Londres. Reino Unido 4Universite Paris-Est Creteil, Centre Hospitalier Universitaire Henri-Mondor, Val de Marne, París. Francia 5Universite Paris Diderot, Beaujon Hospital, Clichy, París. Francia 6Medical University of Vienna, Department of Gastroenterology and Hepatology, Viena. Austria 7University of Toronto, Toronto General Hospital, Toronto, Ontario. Canadá 8Universite de Montreal, Hospital Saint Luc, Montreal, Quebec. Canadá 9Mayo Clinic, Division of Gastroenterology and Hepatology, Phoenix, Arizona. Estados Unidos de América 10Georgetown University, Division of Infectious Diseases, Washington, Distrito de Columbia. Estados Unidos de América 11Weill Cornell Medical College, Division of Gastroenterology and Hepatology, Nueva York. Estados Unidos de América 12Universite Catholique de Louvain, Lovaina. Bélgica 13Gilead Sciences, Inc., Foster City, California. Estados Unidos de América 14University of California, Division of Gastroenterology and Hepatology, San Francisco, California. Estados Unidos de América 15Universita di Torino, Dipartimento di Gastroenterologia, Turín, Piemonte. Italia 16University Hospital Zurich, Department for Gastroenterology and Hepatology, Zurich. Suiza |
Año: | 2017 |
Periodo: | May-Jun |
Volumen: | 16 |
Número: | 3 |
Paginación: | 375-381 |
País: | México |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | Recurrence of HCV infection in patients with chronic hepatitis C virus (HCV) at the time of liver transplantation is nearly universal and reduces the likelihood of graft and patient survival. Materials and methods. Materials and methods. We evaluated outcomes of 17 Materials and methods. patients (16 with HCV genotype 1 and 1 with genotype 4) who received up to 12 or 24 weeks of ledipasvir/sofosbuvir plus ribavirin prior to or up to the time of liver transplant in the SOLAR-1 and SOLAR-2 trials. In all patients, HCV RNA was < 15 IU/mL prior to transplant. At screening, 6 patients were Child-Pugh-Turcotte (CPT) class B and 11 were CPT class C. Seven patients underwent transplant prior to completing assigned treatment, with 4 treated for < 12 weeks. The primary endpoint was posttransplant virologic response 12 weeks after transplant (pTVR12) in patients with HCV RNA < 15 IU/mL at their last measurement prior to transplant. Results. Results. Results. Overall, 94% (16/17) achieved pTVR12. All who achieved pTVR12 received at least 11 weeks of treatment. The single patient who did not achieve pTVR12 discontinued study drug on day 21 and underwent liver transplant the following day. The patient had HCV RNA < 15 IU/mL at post-transplant week 2 but died 15 days post-transplant because of multi-organ failure and septic shock. Conclusion. Conclusion. Conclusion. Among a small population of HCV patients with decompensated cirrhosis, virologic response to ledipasvir / sofosbuvir plus ribavirin prior to liver transplantation was maintained after transplantation, even if treatment was stopped early. Administration of ledipasvir / sofosbuvir plus ribavirin before liver transplant can prevent post-transplant HCV recurrence |
Disciplinas: | Medicina |
Palabras clave: | Gastroenterología, Hepatitis crónica, Hepatitis C, Virus de la hepatitis C, Trasplante de hígado, Terapia antiviral, Recurrencia |
Keyword: | Medicine, Gastroenterology, Chronic hepatitis, Hepatitis C, Hepatitis C virus, Liver transplantation, Antiviral therapy, Recurrence |
Texto completo: | Texto completo (Ver PDF) |