| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000419055 |
| ISSN: | 1665-2681 |
| Autores: | Reggiardo, María Virginia1 Fay, Fabián2 Tanno, Mario1 García Camacho, Gabriela1 Bottaso, Oscar3 Ferretti, Sebastián1 Godoy, Alicia3 Guerrita, Claudio1 Paez, Mauro1 Tanno, Federico1 Ruffinengo, Orlando1 Benetti, Silvina2 García Borrás, Silvia E4 Rossi, M. Celina4 Vorobioff, Julio1 Bessone, Fernando1 Tanno, Hugo1 |
| Instituciones: | 1Hospital Provincial del Centenario, Departamento de Gastroenterología y Hepatología, Rosario, Santa Fe. Argentina 2CIBIC, Rosario, Santa Fe. Argentina 3Universidad Nacional de Rosario, Facultad de Medicina, Rosario, Santa Fe. Argentina 4Universidad Nacional de Rosario, Facultad de Bioquímica y Ciencias Farmacéuticas, Rosario, Santa Fe. Argentina |
| Año: | 2012 |
| Periodo: | Sep-Oct |
| Volumen: | 11 |
| Número: | 5 |
| Paginación: | 658-666 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Studies about the natural history of hepatitis C virus (HCV) infection report variable progression to cirrhosis depending on study design. Retrospective cross-sectional liver clinic studies overestimate the rate of fibrosis progression due to inclusion of patients with more severe disease leaving mild and asymptomatic patients underrepresented. We evaluated fibrosis progression in a group of “healthy” asymptomatic subjects, attending to a voluntary campaign for the detection of HCV infection. Material and methods. A detection campaign was launched on subjects transfused before 1993. Of 1699 volunteers, 61(3.6%) had HCV infection. A liver biopsy was performed in 40 (65%). Assessed risk factors for liver fibrosis were: sex, body mass index, alcohol consumption (> 20 g/d - >40g/d ), genotype, HLA-DRB1 alleles, present age, age at infection and duration of infection. Results. 25 (62.5%) were women with a median age of 52.5 years. The median duration of infection was 21.5 years with a median age at infection of 27 years. As regards fibrosis, 25 (62.5%) had a Low Stage (F0-F1), 8 patients, 20%, had severe fibrosis, one patient (2.5%) had cirrhosis. Alcohol consumption was the only risk factor associated with fibrosis progression. Conclusions. The low progression to cirrhosis may be explained by the clinical characteristics of our population: asymptomatic middle-aged “healthy” subjects infected at young age. The progression to severe fibrosis was noticeable; hence a longer follow-up might demonstrate changes in this outcome. Significant alcohol consumption clearly worsens the natural history of HCV infection; this is no so evident for occasional or mild alcohol consumers |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Virus de la hepatitis C, Fibrosis hepática, Progresión de la enfermedad, Factores de riesgo, Consumo de alcohol |
| Keyword: | Gastroenterology, Hepatitis C virus, Liver fibrosis, Disease progression, Risk factors, Alcohol consumption |
| Texto completo: | Texto completo (Ver PDF) |
