| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000411652 |
| ISSN: | 1665-2681 |
| Autores: | Ferraioli, Giovanna1 Lissandrin, Raffaella1 Tinelli, Carmine2 Scudeller, Luigia2 Bonetti, Federico3 Zicchetti, Mabel1 Longo, Filomena4 Murgia, Mauro5 Bernuzzi, Stefano6 Zecca, Marco3 Casula, Paolo5 Piga, Antonio4 Filice, Carlo1 |
| Instituciones: | 1Universita di Pavia, Pavia, Lombardia. Italia 2Fondazione IRCCS Policlinico San Matteo, Clinical Epidemiology and Biometric Unit, Pavia, Lombardia. Italia 3Fondazione IRCCS Policlinico San Matteo, Pediatric Haematology Oncology, Pavia, Lombardia. Italia 4Universita di Torino, Department of Clinical and Biological Sciences, Turín, Piemonte. Italia 5Ospedale San Martino, Immuno-ematologia e Medicina Trasfusionale, Cerdeña. Italia 6Fondazione IRCCS Policlinico San Matteo, Dipartimento di Medicina Diagnostica e dei Servizi, Pavia, Lombardia. Italia |
| Año: | 2016 |
| Periodo: | May-Jun |
| Volumen: | 15 |
| Número: | 3 |
| Paginación: | 410-417 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | This cross-sectional multicenter study was conducted to investigate any difference in liver stiffness measurements (LSM), evaluated by transient elastography, between patients affected by β thalassaemia major, with and without hepatitis C virus (HCV) infection, and healthy blood donors (controls). Secondary aim was to assess any correlation between transient elastography and serum ferritin, liver magnetic resonance imaging (MRI) T2 or superconductive quantum interference device (SQUID) liver susceptometry values. Materials and methods. The study involved three centers. Transient elastography and MRI T2* examinations were performed in all centers. SQUID liver susceptometry was performed in center1 and center2. T-test for independent data or Mann-Whitney U test was used to analyse differences between two groups. Univariate Pearson’s r coefficient was used to test correlations between liver stiffness measurements and all other variables. Results. In a study with 119 patients and 183 controls, patients who had never been infected with HCV showed significantly higher LSMs than controls [5.7 (95% CI, 5.2- 6.2) kPa vs. 4.3 (95% CI, 4.1-4.4) kPa, p < 0.0001]. A moderate correlation between LSMs and ferritin values, adjusted for gender and age, was found in patients (r = 0.49, p < 0.0001) but not in controls (r = -0.22, p = 0.6). No correlation between LSMs and MRI T2* or SQUID liver susceptometry values was observed. In conclusion, compared to controls β thalassaemia major patients had a significant increase in LSMs independently from HCV infection |
| Disciplinas: | Medicina |
| Palabras clave: | Diagnóstico, Gastroenterología, Betatalasemia, Fibrosis hepática, Sonoelastografía, Imágenes de resonancia magnética |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Beta-thalassemia, Liver fibrosis, Sonoelastography, Magnetic resonance imaging |
| Texto completo: | Texto completo (Ver PDF) |
