| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000411747 |
| ISSN: | 1665-2681 |
| Autores: | Crespo, Javier1 Diago, Moisés2 Cabezas, Joaquín1 Berenguer, Marin3 Broquetas, Teresa4 Serra, Miguel Angel5 Morillas, Rosa6 García Samaniego, Javier7 Calleja, José Luis8 Sánchez, Juan José9 Lens, Sabela10 Soto Fernández, Susana11 Sacristán, Begoña12 Fernández, Inmaculada13 López Núñez, Carmen14 Buti, María15 Romero Gómez, Manuel16 Sáez Royuela, Federico17 Fernández, Conrado18 Jorquera, Francisco19 Pascasio, Juan Manuel21 Cuadrado, Antonio22 Hernández Guerra, Manuel23 |
| Instituciones: | 1Hospital Universitario Marqués de Valdecilla, Santander, Cantabria. España 2Hospital General Valencia, Valencia. España 3Generalitat Valenciana, Hospital La Fe, Valencia. España 4Hospital Universitario del Mar, Barcelona. España 5Universidad de Valencia, Hospital Clínico Universitario, Valencia. España 6Hospital Universitario Trías y Pujol, Badalona, Barcelona. España 7Hospital Carlos III, Madrid. España 8Hospital Universitario Puerta Hierro, Madrid. España 9Hospital Toledo, Toledo, Castilla-La Mancha. España 10Hospital Clinic, Barcelona. España 11Hospital del Tajo, Aranjuez, Madrid. España 12Hospital San Pedro, Logroño, La Rioja. España 13Hospital 12 de Octubre, Madrid. España 14Hospital Universitari de Girona Doctor Josep Trueta, Gerona. España 15Hospital Universitario Vall d'Hebron, Barcelona. España 16Hospital Universitario Valme, Sevilla, Andalucía. España 17Hospital Universitario de Burgos, Burgos. España 18Hospital Universitario de Alcorcón, Alcorcón, Madrid. España 19Complejo Asistencial Universitario León, León, Castilla y León. España 20Hospital Universitario Rio Hortega, Valladolid. España 21Hospital Universitario Virgen del Rocío, Sevilla, Andalucía. España 22Hospital Comarcal de Laredo, Laredo, Cantabria. España 23Hospital Universitario de Canarias, Tenerife, Santa Cruz de Tenerife. España |
| Año: | 2015 |
| Periodo: | Jul-Ago |
| Volumen: | 14 |
| Número: | 4 |
| Paginación: | 477-486 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Telaprevir-based therapy (TBT) has been extensively evaluated in clinical trials. So we designed a study to compare the efficacy and safety of TBT between patients with moderate fibrosis and those suffering from advanced fibrosis in clinical practice. A multicenter observational and ambispective study was conducted. It included 582 patients with chronic hepatitis C genotype 1, 214 with fibrosis F2, and 368 with F3/F4 (F3: 148; F4: 220). Results. The mean patient age was 55 years, 67% male. Type of prior response was 22% naïve, 57% relapsers, and 21% partial/null responders, 69% had high viral load (> 800,000 IU/mL). HCV genotypes were 1a (19%), 1b (69%), and 1 (12%), respectively. Sixty-five percent were non-CC IL28B genotype. Week-12 sustained virologic response (SVR12) was significantly higher among F2-naïve patients (78%) compared with F3/F4-naïve patients (60%; p = 0.039) and among F2 non-responders (67%) compared with F3/F4 non-responders (42%; p = 0.014). SVR12 among relapsers was remarkably high in both groups (F2:89% vs. F3/F4:78%). Severe anemia and thrombocytopenia were more frequent among patients with F3/F4 than those with F2 (p < 0.01). Overall, 132 patients (22%) discontinued treatment: 58 due to adverse effects, 42 due to the stopping-rule, and 32 due to breakthrough. Premature discontinuation was more frequent among patients with F3/F4 (p = 0.028), especially due to breakthrough (p < 0.001). Conclusions. This multicenter study demonstrates high efficacy and an acceptable safety profile with regard to TBT in F2-patients in clinical practice |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Gastroenterología, Hepatitis C, Fibrosis hepática, Telaprevir, Respuesta viral |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Hepatitis C, Liver fibrosis, Telaprevir, Viral response |
| Texto completo: | Texto completo (Ver PDF) |
