| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000418095 |
| ISSN: | 1665-2681 |
| Autores: | Hsuan-Wei Chen1 Hsin-Hung Huang1 Ching-Huang Lai2 Wei-En Chang3 Yu-Lueng Shih1 Wei-Kuo Chang1 Tsai-Yuan Hsieh1 Heng-Cheng Chu1 |
| Instituciones: | 1Tri-Service General Hospital, Division of Gastroenterology and Hepatology, Taipei. Taiwán 2National Defense Medical Center, School of Public Health, Taipei. Taiwán 3Hualien Armed Forces General Hospital, Department of Internal Medicine, Taipei. Taiwán |
| Año: | 2013 |
| Periodo: | Feb |
| Volumen: | 12 |
| Paginación: | 78-84 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, analítico |
| Resumen en inglés | The aim of this study is to evaluate the role of hepatitis C virus (HCV) infection in patients with primary biliary cirrhosis (PBC). Material and methods. On the basis of a retrospective review of medical records, all patients consecutively diagnosed with PBC or HCV infection between 1999 and 2011 and who had a regular follow-up of at least 3 years were included in the study. Clinical characteristics, especially the severity of cirrhosis, were analyzed in PBC patients with HCV infection (PBC-HCV), PBC patients without HCV infection (PBC-only), and patients with only HCV infection (HCV-only). Results. A total of 76 patients with PBC, including 9 patients with HCV infection, were analyzed. Of the PBC-HCV patients, 7 (7/9, 77.8%) were women with a mean age of 55.11 ± 14.29 years. Age- and sex-matched PBC-only patients (n = 36) and HCV-only patients (n = 36) were used as control groups. In comparison to the PBC-only controls, PBC-HCV patients had a greater severity of cirrhosis based on Child-Pugh (p = 0.019) and Model for End-Stage Liver Disease (MELD) (p = 0.01) scores. However, no significant difference in the severity of cirrhosis was found between the PBC-HCV and HCV-only control patients (p = 0.94 in Child-Pugh scores; p = 0.64 in MELD scores). Conclusions. In PBC patients with concomitant HCV infection, aggressive management may be warranted in view of the associated more severe liver cirrhosis |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Diagnóstico, Hepatitis C, Cirrosis biliar, Escala Child-Pugh, Enfermedad hepática terminal |
| Keyword: | Gastroenterology, Diagnosis, Hepatitis C, Biliary cirrhosis, Child-Pugh Scale, End-stage liver disease |
| Texto completo: | Texto completo (Ver PDF) |
