| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000418069 |
| ISSN: | 1665-2681 |
| Autores: | Attallah, Abdelfattah M1 Abdallah, Sanaa O2 Attallah, Ahmed A1 Omran, Mohamed M1 Farid, Khaled3 Nasif, Wesam A4 Shiha, Gamal E5 Abdel-Aziz, F6 Rasafy, Nancy1 Shaker, Yehia M7 |
| Instituciones: | 1Biotechnology Research Center, Research Department, New Damietta. Egipto 2Cairo University, Faculty of Science, Giza. Egipto 3Helwan University, Faculty of Science, Helwan, Cairo. Egipto 4Minufiya University, Genetic Engineering and Biotechnology Research Institute, Minufiya. Egipto 5Mansoura University, Faculty of Medicine, Mansoura. Egipto 6Mansoura University, Faculty of Science, Mansoura. Egipto 7National Research Center, El Cairo. Egipto |
| Año: | 2013 |
| Periodo: | Feb |
| Volumen: | 12 |
| Paginación: | 44-53 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado |
| Resumen en inglés | Several noninvasive predictive models were developed to substitute liver biopsy for fibrosis assessment. Aim. To evaluate the diagnostic value of fibronectin which reflect extracellular matrix metabolism and standard liver functions tests which reflect alterations in hepatic functions. Material and methods. Chronic hepatitis C (CHC) patients (n = 145) were evaluated using ROC curves and stepwise multivariate discriminant analysis (MDA) and was validated in 180 additional patients. Liver biochemical profile including transaminases, bilirubin, alkaline phosphatase, albumin, complete blood count were estimated. Fibronectin concentration was determined using monoclonal antibody and ELISA. Results. A novel index named fibronectin discriminant score (FDS) based on fibronectin, APRI and albumin was developed. FDS produced areas under ROC curves (AUC) of 0.91 for significant fibrosis and 0.81 for advanced fibrosis. The FDS correctly classified 79% of the significant liver fibrosis patients (F2-F4) with 87% sensitivity and 75% specificity. The relative risk [odds ratio (OR)] of having significant liver fibrosis using the cut-off values determined by ROC curve analyses were 6.1 for fibronectin, 4.9 for APRI, and 4.2 for albumin. FDS predicted liver fibrosis with an OR of 16.8 for significant fibrosis and 8.6 for advanced fibrosis. The FDS had similar AUC and OR in the validation group to the estimation group without statistically significant difference. Conclusion. FDS predicted liver fibrosis with high degree of accuracy, potentially decreasing the number of liver biopsy required |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Diagnóstico, Marcadores hematológicos, Diagnóstico no invasivo, Análisis discriminante, Fibrosis hepática, Hepatitis C |
| Keyword: | Gastroenterology, Diagnosis, Hematologic markers, Non invasive diagnosis, Discriminant analysis, Liver fibrosis, Hepatitis C |
| Texto completo: | Texto completo (Ver PDF) |
