| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000419210 |
| ISSN: | 1665-2681 |
| Autores: | Khattab, Mahmoud A1 Eslam, Mohammed1 Mousa, Yousef I1 Ela-Adawy, Nosa1 Fathy, Shimaa1 Shatat, Mohammed1 Abd-Aalhalim, Hesham1 Kamal, Amal1 Sharawe, Mohammed A1 |
| Instituciones: | 1Minia University, Department of Internal Medicine, Minia. Egipto |
| Año: | 2012 |
| Periodo: | Jul-Ago |
| Volumen: | 11 |
| Número: | 4 |
| Paginación: | 487-494 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | Metabolic syndrome is recognised as a potential risk factor for the development of hepatocellular carcinoma (HCC). The association between metabolic factors and hepatitis C (HCV)-related HCC has not yet been well clarified. This study was conducted to elucidate the role of metabolic factors in HCV-related HCC. Material and methods. We recruited 147 HCC patients and compared them with 147 matched CHC patients and 320 controls. The plasma levels of homeostasis model assessment-IR (HOMA-IR), adiponectin and lipids for all participants were assessed. Results. The HCC group showed significantly higher levels of insulin, glucose, HOMA-IR and adiponectin as well as lower levels of total cholesterol, HDL-C, LDL-C, and triglycerides compared with the matched CHC patients and controls. HOMA-IR did not correlate with pathologic features of HCC, whereas serum adiponectin levels correlated positively with the size of tumour nodules (P = 0.009). Based on stepwise logistic regression analysis, age (OR: 1.456, 95% CI: 1.072- 1.979, P < 0.01), HOMA-IR (OR: 2.50, 95% CI: 1.70-3.69, P = 0.001), and adiponectin (OR: 1.585, 95% CI: 1.269- 1.980, P = 0.001) were independently associated with HCC. Conclusions. Metabolic abnormalities are closely associated with the occurrence and development of HCV-related HCC. Patients with CHC and high serum adiponectin levels face a higher risk of developing liver cancer. Insulin resistance, as measured by HOMA-IR, is significantly associated with HCV-related HCC |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Metabolismo y nutrición, Diagnóstico, Hepatitis C, Resistencia a la insulina, Carcinoma hepatocelular |
| Keyword: | Gastroenterology, Metabolism and nutrition, Diagnosis, Hepatitis C, Hepatocellular carcinoma |
| Texto completo: | Texto completo (Ver PDF) |
