| Revista: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000419059 |
| ISSN: | 1665-2681 |
| Autores: | Shah, Neeral L1 Northup, Patrick G1 Caldwell, Stephen H1 |
| Instituciones: | 1University of Virginia, University of Virginia Medical Center, Charlottesville, Virginia. Estados Unidos de América |
| Año: | 2012 |
| Periodo: | Sep-Oct |
| Volumen: | 11 |
| Número: | 5 |
| Paginación: | 686-690 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | The relative incidence of bleeding and thrombotic events and the use of blood products in hospitalized cirrhosis patients have not been widely reported. We aimed to estimate the magnitude of bleeding events and venous thrombosis in consecutive hospitalized cirrhotic patients over a finite time period and to examine the amount and indications for blood product use in cirrhosis patients admitted to a tertiary care center. Results. Among patients admitted with decompensated liver disease, 34 (40%) suffered bleeding events (about one-half non-variceal) and 6 patients (7%) suffered deep venous thrombosis. In the blood product survey, 168 patients were transfused with plasma or platelets during the survey intervals. Liver disease patients accounted for 7.7% of the total but disproportionately consumed 32.4% (46 of 142) of the units of plasma mostly administered as prophylaxis. In contrast, cirrhosis patients received only 7 of the 53 units of platelets transfused (13.2%) during the survey intervals. Conclusions. Coagulation issues constitute a common problem in patients with liver disease. Recent advances in laboratory testing have shown that stable cirrhosis patients are relatively hypercoagulable. The result of this prospective survey among decompensated (unstable) cirrhosis patients shows that, while DVT is not uncommon, bleeding (non-variceal in one half) remains the dominant clinical problem. This situation likely sustains the common practice of plasma infusion in these patients although its use is of unproven and questionable benefit. Better clinical tools are needed to refine clinical practice in this setting |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Hematología, Cirrosis hepática, Transfusión sanguínea, Bancos de sangre, Plasma, Plaquetas |
| Keyword: | Gastroenterology, Hematology, Liver cirrhosis, Blood transfusion, Blood banks, Plasma, Platelets |
| Texto completo: | Texto completo (Ver PDF) |
