Synthesis, characterization and antimicrobial activity of Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands against bacteria and yeasts of clinical importance
Título del documento: Synthesis, characterization and antimicrobial activity of Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands against bacteria and yeasts of clinical importance
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000436287
ISSN: 0001-3765
Autores: 1
2
1
1
1
3
2
2
1
Instituciones: 1Universidade Federal de Sao Joao del Rei, Laboratorio de Microbiologia Medica, Divinopolis, Minas Gerais. Brasil
2Universidade Federal de Sao Joao del Rei, Laboratorio de Compostos Bioativos e Cataliticos, Divinopolis, Minas Gerais. Brasil
3Universidade Federal de Sao Joao del Rei, Laboratorio de Farmacologia da Dor e Inflamacao, Divinopolis, Minas Gerais. Brasil
Año:
Volumen: 91
Número: 4
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Four novel Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands were synthesized and characterized using elemental, physiochemical, and spectroscopy analytical methods. The results showed the formation of ligands coordinated by sulfur atoms of the C = S bond to the L1 ligand and by the sulfur atom of the C-S bond and/or nitrogen of the intra C-ring bond of the L2 ligand. The activity of the complexes against Gram-negative, Gram-positive bacteria and yeasts of clinical importance was evaluated by broth microdilution method. The best result was obtained to L2-Ni compound against E. cloacae (Minimal Inhibitory Concentration (MIC) = 62.5 µg/mL). Additionally, the compounds showed anti-Candida activity (MIC values ranging from 250 to 500 µg/mL), except the L1-Cr that was not active against any tested microorganism
Disciplinas: Química,
Medicina
Palabras clave: Farmacología,
Complejos organometálicos,
Cromo,
Cobalto,
Níquel,
1,2-bis-bis (2-tiazolin-2-isulfanil) etano,
Actividad antimicrobiana
Keyword: Pharmacology,
Organometallic complexes,
Chromium,
Cobalt,
Nickel,
1,2-bis-bis (2-thiazolin-2-isulfanyl) ethane,
Antimicrobial activity
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