| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000436193 |
| ISSN: | 0001-3765 |
| Autores: | Cordeiro, Cleydson F1 Bettio, Ingrid1 Trevisan, Marcello G1 |
| Instituciones: | 1Universidade Federal de Alfenas, Instituto de Quimica, Alfenas, Minas Gerais. Brasil |
| Año: | 2020 |
| Volumen: | 92 |
| Número: | 1 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Fosamprenavir calcium is an amprenavir prodrug of the protease inhibitors class used in the treatment of patients with acquired immunodeficiency syndrome (AIDS). Different solid forms of this drug are described in patents, in this sense studies on the physico-chemical characterization and stability are relevant for the selection of a solid form with adequate features for pharmaceutical purposes. In the present work form I (commercial) and amorphous of fosamprenavir calcium were characterized by the techniques of Differential Scanning Calorimetry (DSC), Thermogravimetry (TGA), Powder X-ray Diffraction (PXRD), Fourier-Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). Furthermore, the chemical and polymorphic stability of the commercial form were evaluated by DSC, PXRD, FTIR and High-Performance Liquid Chromatography (HPLC). In the studies of characterization, thermal analyses allied to spectroscopic methods (PXRD and FTIR) demonstrated that the presence of water in the crystalline structure of Form I is fundamental for maintaining its crystallinity. In studies of accelerated stability the techniques of DSC, PXRD and FTIR showed that Form I does not suffer phase change when submitted to controlled conditions of temperature and humidity. Moreover, HPLC and FTIR proved the chemical stability of this solid form of fosamprenavir, thus demonstrating its suitability for pharmaceutical purposes |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Inmunología, SIDA, Inhibidores enzimáticos, Proteasas, Estabilidad química, Polimorfismo, Fosamprenavir |
| Keyword: | Pharmacology, Immunology, AIDS, Enzymatic inhibitors, Proteases, Chemical stability, Polymorphism, Fosamprenavir |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
