| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000424349 |
| ISSN: | 0001-3765 |
| Autores: | Lopes, Lourdes C.S1 Brito, Lucas M2 Bezerra, Thayllan T1 Gomes, Kleyton N1 Carvalho, Fernando A. de A2 Chaves, Mariana Helena1 Cantanhede, Welter1 |
| Instituciones: | 1Universidade Federal do Piaui, Departamento de Quimica, Teresina, Piaui. Brasil 2Universidade Federal do Piaui, Nucleo de Pesquisas em Plantas Medicinais, Teresina, Piaui. Brasil |
| Año: | 2018 |
| Periodo: | Sep |
| Volumen: | 90 |
| Número: | 3 |
| Paginación: | 2679-2690 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Gold (Au0) and silver (Ag0) nanoparticles were synthesized using tannic acid (TA) as both reducing and stabilizer. Nanoparticles formation, stability, and interaction with TA were compared to citrate-coated nanoparticles and monitored by UV-Vis, zeta potential, and transmission electron microscopy. TA coating resulted in a red-shift and broadening of bands compared to citrate-coated nanoparticles (NPs-Cit). AgNPs-TA and AuNPs-TA are negatively charged with mean surface charge of -29.4 mV and -29.6 mV, respectively. TEM images showed polydispersety of AuNPs-TA (6-42 nm) and aggregation of AgNPs-TA (12-71 nm). In vitro assays of Leishmania amazonensis promastigotes showed an increment of antileishmanial activity for AgNPs-TA in relation to AgNPs-Cit, while AuNPs-TA and AuNPs-Cit did not affect the protozoas at tested concentrations. CC50 value for AgNPs-TA suggested that TA attenuates nanosilver toxicity comparatively to its precursor (Ag+). This investigation can contribute to the development of new, green, and fast produced drugs aiming at leishmaniasis treatment |
| Disciplinas: | Biología, Química, Medicina |
| Palabras clave: | Química farmacéutica, Parasitología, Nanopartículas de oro, Nanopartículas de plata, Síntesis química, Acido tánico, Química verde, Leishmaniasis, Actividad citotóxica |
| Keyword: | Medicinal chemistry, Parasitology, Gold nanoparticles, Silver nanoparticles, Chemical synthesis, Tannic acid, Green chemistry, Leishmaniasis, Cytotoxic activity |
| Texto completo: | Texto completo (Ver HTML) |
