| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000436208 |
| ISSN: | 0001-3765 |
| Autores: | Guo, Huan1 Zeng, Xiangting3 Li, Haining2 Guo, Yanxiang2 Wang, Tao2 Guo, Hongyun2 Zhu, Gongjian2 Wang, Lan2 Zhou, Haihong2 Liu, Kedan2 Chen, Xiaoyi2 Wang, Haitao2 Zhao, Xinke4 Su, Haixiang2 Li, Yingdong1 |
| Instituciones: | 1Lanzhou University, School of Basic Medical Sciences, Lanzhou, Gansu. China 2Gansu Provincial Academic Institute for Medical Sciences, Gansu Provincial Cancer Hospital, Lanzhou, Gansu. China 3Lanzhou University Second Hospital, Department of general surgery, Lanzhou, Gansu. China 4Gansu University of Chinese Medicine, Lanzhou, Gansu. China |
| Año: | 2020 |
| Volumen: | 92 |
| Número: | 1 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Circulating miRNAs presenting in plasma in a stable manner have been demonstrated their potential role as a promising biomarkers in many human diseases, such as Alzheimer’s disease, melanoma and ovarian carcinoma. However, few circulating miRNAs could be used for breast ductal cancer diagnosis. Here, we identified miR-1273g-3p as a biomarker for detecting breast ductal cancer. We detected miR-1273g-3p levels in the plasma of 39 sporadic breast ductal cancer patients and 40 healthy donors by Stem-loop Quantitative Real-time PCR (qRT-PCR). The results showed the plasma miR-1273g-3p level were significantly up-regulated in breast ductal cancer patients compared with healthy donors (p=0.0139). Receiver operating characteristic (ROC) curve also revealed the significantly diagnostic ability of miR-1273g-3p in patients (p=0.0414). In addition, the plasma level of miR-1273g-3p was closely related to IIIB-IIIC TNM stage. We also confirmed the higher expression level of miR-1273g-3p in breast cancer cell lines MCF-7 (4.872±0.537) than normal breast cells (Hs 578Bst). Taken together, miR-1273g-3p could represent as a potential biomarker for early breast ductal cancer diagnosis |
| Disciplinas: | Medicina |
| Palabras clave: | Oncología, Diagnóstico, Carcinoma ductal mamario, Biomarcadores, ARN mitocondrial, Plasma |
| Keyword: | Oncology, Diagnosis, Breast ductal carcinoma, Plasma, Mitochondrial RNA, Biomarkers |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
