Molluscicidal activity of Persea americana Mill. (Lauraceae) stem bark ethanolic extract against the snail Biomphalaria glabrata (Say, 1818): a novel plant-derived molluscicide?



Título del documento: Molluscicidal activity of Persea americana Mill. (Lauraceae) stem bark ethanolic extract against the snail Biomphalaria glabrata (Say, 1818): a novel plant-derived molluscicide?
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000435790
ISSN: 0001-3765
Autores: 1
2
3
4
4
5
1
1
Instituciones: 1Universidade Estadual de Goias, Laboratorio de Farmacologia e Toxicologia de Produtos Naturais e Sinteticos, Anapolis, Goias. Brasil
2Universidade Estadual de Goias, Laboratorio da Interacao Parasito-Hospedeiro, Anapolis, Goias. Brasil
3Universidade Federal de Goias, Laboratorio de Biotecnologia Ambiental e Ecotoxicologia, Goiania, Goias. Brasil
4Universidade Federal de Goias, Laboratorio de Estudos da Relacao Parasito-Hospedeiro, Goiania, Goias. Brasil
5Universidade Federal de Goias, Instituto de Ciencias Biologicas, Goiania, Goias. Brasil
Año:
Volumen: 92
Número: 4
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Plant-derived molluscicides have been indicated as biodegradable and low-cost strategies for control of Biomphalaria spp., intermediate host for the Schistosoma. This study evaluated whether the crude ethanolic extract of the Persea americana stem bark has molluscicidal activity against embryos, newly-hatched and adults of Biomphalaria glabrata. The extract was obtained, characterized and its toxicity analyzed by snail embryotoxicity test (144 h) and acute toxicity test with newly-hatching and adult snails (96 h). Results showed the presence of flavonoids, anthraquinone heterosides, coumarins and tannins in the crude ethanolic extract, which showed molluscicidal activity against all life cycle stages of B. glabrata. The LC50 for embryos, newly-hatched and adults were 27.06, 30.60 and 55.55 ppm, respectively. Embryos exposed to the extract at 50 ppm showed hatching inhibition and at 6.2 and 25 ppm had the highest rates of morphological alterations, such as shell malformations and coagulation of the perivitelline substance. Adult snails exposed to the extract at 75 ppm showed a peak of behavioral changes, such as lethargy and shell reclusion, in addition to answers like hemolymph release in most concentrations. Further studies are required, prioritizing toxicity testing on non-target organisms and further elucidation of the active molecules
Disciplinas: Biología,
Química
Palabras clave: Fitoquímica,
Angiospermas,
Moluscos,
Esquistosomiasis,
Vectores biológicos,
Extractos vegetales,
Flavonoides,
Embriotoxicidad,
Actividad molusquicida,
Hospederos intermediarios,
Biomphalaria glabrata,
Schistosoma mansoni,
Persea americana,
Lauraceae
Keyword: Phytochemistry,
Angiosperms,
Molluscs,
Schistosomiasis,
Biological vectors,
Plant extracts,
Flavonoids,
Embryotoxicity,
Molluscicide activity,
Intermediate hosts,
Schistosoma mansoni,
Biomphalaria glabrata,
Persea americana,
Lauraceae
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