| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000418070 |
| ISSN: | 0001-3765 |
| Autores: | Camassa, Jose A1 Diogo, Camila C1 Sousa, Cristina P2 Azevedo, Jorge T1 Viegas, Carlos A1 Reis, Rui L3 Dourado, Nuno4 |
| Instituciones: | 1Universidade de Tras-os-Montes e Alto Douro, Escola de Ciencias Agrarias e Veterinarias, Vila Real. Portugal 2Centro Hospitalar do Porto, Porto. Portugal 3Universidade do Minho, Parque de Ciencia e Tecnologia, Braga. Portugal 4Universidade do Minho, Departamento de Engenharia Mecanica, Guimaraes. Portugal |
| Año: | 2017 |
| Periodo: | Mar |
| Volumen: | 89 |
| Número: | 1 |
| Paginación: | 231-246 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also during skeletal growth. Pre-clinical and translational studies using BTMs with sheep and goats as animal models in orthopaedic research studies to help in the evaluation of the fracture healing process and osteoporosis research are also described in this review. The available information from the reviewed studies was systematically organized in order to highlight the most promising BTMs in small ruminant research, as well as provide a wide view of the use of sheep and goat as animal models in orthopaedic research, type of markers and commercial assay kits with cross-reactivity in sheep and goat, method of sample and storage of serum and urine for bone turnover markers determination and the usefulness and limitations of bone turnover markers in the different studies, therefore an effective tool for researchers that seek answers to different questions while using BTMs in small ruminants |
| Disciplinas: | Medicina veterinaria y zootecnia, Medicina |
| Palabras clave: | Medicina experimental, Traumatología y ortopedia, Metabolismo óseo, Marcadores óseos, Ovejas |
| Keyword: | Experimental medicine, Traumatology and orthopedics, Bone metabolism, Bone markers, Sheep |
| Texto completo: | Texto completo (Ver HTML) |
